The Sutherland Research Group: Publications

2024

R. Clarke, L. Zeng, B. C. Atkinson, M. Kadodwala, A. R. Thomson and A. Sutherland, Fluorescent Carbazole-Derived α-Amino Acids: Structural Mimics of Tryptophan. Chem. Sci., 2024, DOI:10.1039/d4sc01173b. Selected for the 2024 HOT article collection.

Carbazoles AA

H. McErlain, M. J. Andrews, A. J. B. Watson, S. L. Pimlott and A. Sutherland, Ligand-Enabled Copper-Mediated Radioiodination of Arenes. Org. Lett., 2024, 26, 1528-1532. DOI:10.1021/acs.orglett.4c00356.

RadioIodGA

L. J. N. Waddell, C. Wilson and A. Sutherland, Trifluoromethylthiolation of Arenes Using Lewis Acid and Lewis Base Dual Catalysis, J. Org. Chem., 2024, 89, 1275-1284. DOI:10.1021/acs.joc.3c02571.

CF3S JOC

A. Knyzeliene, M. G. MacAskill, C. J. Alcaide-Corral, T. E. F. Morgan, M. C. Henry, C. Lucatelli, S. L. Pimlott, A. Sutherland and A. A. S. Tavares, [18F]LW223 has Low Non-Displaceable Binding in Murine Brain, Enabling High Sensitivity TSPO PET Imaging, J. Cereb. Blood Flow Metab., 2024, 44, 397-406. DOI:10.1177/0271678X231205661.

JCBFM Graph

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2024, 41, 157-161.

2023

A. C. Dodds, H. G. Sansom, S. W. Magennis and A. Sutherland, Synthesis of Thiazoloindole α-Amino Acids: Chromophores Amenable to One- and Two-Photon Induced Fluorescence, Org. Lett., 2023, 25, 8942-8946. DOI:10.1021/acs.orglett.3c03851.

Trp AA GA

S. Songsri, A. H. Harkiss and A. Sutherland, Synthesis and Photophysical Properties of Charge-Transfer-Based Pyrimidine-Derived α-Amino Acids, J. Org. Chem., 2023, 88, 13214-13224. DOI:10.1021/acs.joc.3c01437.

Pyrimidines (GA)

R. McGrory, R. Clarke, O. Marshall and A. Sutherland, Fluorescent α-Amino Acids via Heck-Matsuda Reactions of Phenylalanine-Derived Arenediazonium Salts, Org. Biomol. Chem., 2023, 21, 6932-6939. DOI:10.1039/d3ob01096a.

PheGA

R. McGrory, D. C. Morgan, A. G. Jamieson and A. Sutherland, Rotamer-Controlled Dual Emissive α-Amino Acids, Org. Lett., 2023, 25, 5844-5849. DOI:10.1021/acs.orglett.3c02112.

OLAA

L. J. N. Waddell, M. R. Senkans and A. Sutherland, Regioselective C-H Thiocyanation of Arenes by Iron(III) Chloride, J. Org. Chem., 2023, 88, 7208-7218. DOI:10.1021/acs.joc.3c00454.

Thiocyana GA

A. C. Dodds, L. J. N. Waddell and A. Sutherland, Regioselective Functionalization of Arenes Using Iron Triflimide Catalysis, Synlett, 2023, 34, 1852-1865. DOI:10.1055/s-0042-1751445. Research Account.

SLGA

L. M. Riley, T. N Mclay and A. Sutherland, Synthesis and Fluorescent Properties of Alkynyl- and Alkenyl-Fused Benzotriazole-Derived α-Amino Acids, J. Org. Chem., 2023, 88, 2453-2463. DOI:10.1021/acs.joc.2c02886.

Benzo2GA

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2023, 40, 223-227, 761-765, 1066-1070, 1298-1302, 1590-1594, 1816-1821.

HOTP2023 

2022

H. McErlain, E. B. McLean, T. E. F. Morgan, V. K. Burianova, A. A. S. Tavares and A. Sutherland, Organocatalytic Asymmetric Synthesis of SynVesT-1, a Synaptic Density Positron Emission Tomography Imaging Agent, J. Org. Chem., 2022, 87, 14443-14451. DOI:10.1021/acs.joc.2c01895. Article was highlighted in SYNFACTS.

MNI GA

V. Tabouillot, R. Kumar, P. L. Lalaguna, M. Hajji, R. Clarke, A. S. Karimullah, A. R. Thomson, A. Sutherland, N. Gadegaard, S. Hashiyada and M. Kadodwala, Near-Field Probing of Optical Superchirality with Plasmonic Circularly Polarized Luminescence for Enhanced Bio-Detection, ACS Photonics, 2022, 9, 3617-3624. DOI:101021/acsphotonics.2c01073.

Photo(GA)

L. J. N. Waddell, M. C. Henry, M. A. B. Mostafa and A. Sutherland, One-Pot Synthesis of Diaryl Sulfonamides using an Iron- and Copper-Catalyzed Aryl C-H Amidation Process, Synthesis, 2022, 54, 4551-4560. DOI:10.1055/a-1884-6988.

SynthesisGA

A. C. Dodds, S. Puddu and A. Sutherland, Thioarylation of Anilines using Dual Catalysis: Two-Step Synthesis of Phenothiazines, Org. Biomol. Chem., 2022, 20, 5602-5614. DOI:10.1039/d2ob01082h.

GA Phenothiazines

A. C. Dodds and A. Sutherland, Synthesis of Phenoxathiins using an Iron-Catalysed C-H Thioarylation, Org. Biomol. Chem., 2022, 20, 1738-1748. DOI:10.1039/d2ob00022a.

Phenox GA

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2022, 39, 217-221, 737-741, 1117-1121, 1539-1543, 1904-1909, 2209-2214.

GAHOTP2022

2021
 
H. McErlain, L. M. Riley and A. Sutherland, Palladium-Catalyzed C-P Bond Forming Reactions of Aryl Nonaflates Accelerated by Iodide, J. Org. Chem., 2021, 86, 17036-17049. DOI:10.1021/acs.joc.1c02172.

C-P GA

M. G. MacAskill, C. Wimberley, T. E. F. Morgan, C. J. Alcaide-Corral, D. E. Newby, C. Lucatelli, A. Sutherland, S. L. Pimlott and A. A. S. Tavares, Modelling [18F]LW223 PET Data using Simplified Imaging Protocols for Quantification of TSPO Expression in the Rat Heart and Brain, Eur. J. Nucl. Med. Mol. Imag., 2021, 49, 137-145. DOI:10.1007/s00259-021-05482-1.

EJNMI (GA)

R. McGrory, R. J. Faggyas and A. Sutherland, One-Pot Synthesis of N-Substituted Benzannulated Triazoles via Stable Arene Diazonium Salts, Org. Biomol. Chem., 2021, 19, 6127-6140. DOI:10.1039/d1ob00968k. Article was selected for the themed collection: "Synthetic Methodology in OBC".

Benzo(GA)

T. E. F. Morgan, L. M. Riley, A. A. S. Tavares and A. Sutherland, Automated Radiosynthesis of cis- and trans-4-[18F]Fluoro-L-proline Using [18F]Fluoride, J. Org. Chem., 2021, 86, 14054-14060. DOI:10.1021/acs.joc.1c00755. Special issue: Enabling Technologies for  Organic Synthesis.

Fluoropro

A. C. Dodds and A. Sutherland, Regioselective C-H Thioarylation of Electron-Rich Arenes by Iron(III) Triflimide Catalysis, J. Org. Chem., 2021, 86, 5922-5932. DOI:10.1021/acs.joc1c00448.

Sulf(JOC)

M. G. MacAskill, A. Stadulyte, L. Williams, T. E. F. Morgan, N. L. Sloan, C. J. Alcaide-Corral, T. Walton, C. Wimberley, C.-A. McKenzie, N. Spath, W. Mungall, R. BouHaidar, M. R. Dweck, G. A. Gray, D. E. Newby, C. Luctatelli, A. Sutherland, S. L. Pimlott and A. A. S. Tavares, Quantification of Macrophage-Driven Inflammation during Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism, J. Nucl. Med., 2021, 62, 536-544. DOI:10.2967/jnumed.120.243600. JNM Editor's Best Basic Science Article of 2021.

GAJNM

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2021, 38, 287-291, 677-681, 1053-1057, 1418-1422, 1715-1719, 2139-2144.

NMR Abs

2020


E. Dubost, H. McErlain, V. Babin, A. Sutherland and T. Cailly, Recent Advances in Synthetic Methods for Radioiodination, J. Org. Chem., 2020, 85, 8300-8310. DOI:10.1021/acs.joc.0c00644. ACS Editors' Choice.

JOCSynFC

M. C. Henry and A. Sutherland, Synthesis of Benzo[b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis, Org. Lett., 2020,  22, 2766-2770. DOI:10.1021/acs.orglett.0c00754.

Benzofurans (OL)

D. E. Sood, S. Champion, D. Dawson, S. Chabbra, B. Bode, A. Sutherland and A. J. B. Watson, Deoxyfluorination using CuF2 Enabled by a Lewis Base Activating Group Strategy, Angew. Chem. Int. Ed., 2020, 59, 8460-8463.  DOI:10.1002/anie.202001015.

ACIE Fluoro

M. C Henry, V. M. Abbinante and A. Sutherland, Iron-Catalyzed Regioselective Synthesis of 2-Arylbenzoxazoles and 2-Arylbenzothiazoles via Alternative Reaction Pathways, Eur. J. Org. Chem., 2020, 2819-2826.  DOI:10.1002/ejoc.202000014.

Benzox GA

J. D. Bell, A. H. Harkiss, D. Nobis, E. Malcolm, A. Knuhtsen, C. R. Wellaway, A. G. Jamieson, S. W. Magennis and A. Sutherland, Conformationally Rigid Pyrazoloquinazoline
α-Amino Acids: One- and Two-Photon Induced Fluorescence, Chem. Commun., 2020, 56, 1887-1890. DOI:10.1039/C9CC09064A.

CC GA

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2020, 37, 145-149, 472-476, 747-751, 1038-1042, 1294-1299, 1556-1560.

Graph2020

2019

A. Sutherland, S. Pimlott, A. Tavares and C. Lucatelli, TSPO Binders. W.O. Patent WO2019243616 A1, December 26, 2019.

J. D. Bell, T. E. F. Morgan, N. Buijs, A. H. Harkiss, C. R. Wellaway and A. Sutherland, Synthesis and Photophysical Properties of Benzotriazole-Derived Unnatural α-Amino Acids, J. Org. Chem., 2019, 84, 10436-10448.  DOI:10.1021/acs.joc.9b01685.

Benzo(GA)

A. Sutherland, Radiohalogenation of Organic Compounds: Practical Considerations and Challenges for Molecular Imaging, Synthesis, 2019, 51, 4368-4373. DOI:10.1055/s-0037-1611885. Invited submission for a special topic: Halogenation methods (with a view towards radioimaging applications). Article Featured on the Front Cover.

Radiosyn GA

M. C. Henry, R. McGrory, R. J. Faggyas, M. A. B. Mostafa and A. Sutherland, One-Pot ortho-Amination of Aryl C-H Bonds Using Consecutive Iron and Copper Catalysis, Org. Biomol. Chem., 2019, 17, 4629-4639. DOI:10.1039/C9OB00712A
Article was selected for the themed collection: "Synthetic Methodology in OBC".

CN OBC

R. J. Faggyas, N. L. Sloan, N. Buijs and A. Sutherland, Synthesis of Structurally Diverse Benzotriazoles via Rapid Diazotization and Intramolecular Cyclization of 1,2-Aryldiamines, Eur. J. Org. Chem., 2019, 5344-5353.  DOI:10.1002/ejoc.201900463. Invited contribution to a special issue on "Heterocycles".  Article was also featured on ChemistryViews.


EJOC
              GA

M. G. MacAskill, T. Walton, L. Williams, T. E. F. Morgan, C. J. Alcaide-Corral, M. R. Dweck, G. A. Gray, D. E. Newby, C. Lucatelli, A. Sutherland, S. L. Pimlott, A. A. S. Tavares, Kinetic Modelling and Quantification Bias in Small Animal PET Studies with [18F]AB5186, a Novel 18 kDa Translocator Protein Radiotracer, PLoS ONE, 2019, 14, e0217515. DOI:10.1371/journal.pone.0217515.

PLOS(GA)

J. J. Molloy, K. M. O'Rourke, C. P. Frias, N. L. Sloan, M. J. West, S. L. Pimlott, A. Sutherland and A. J. B. Watson, Mechanism of Cu-Catalyzed Aryl Boronic Acid Halodeboronation Using Electrophilic Halogen: Development of a Base-Catalyzed Iododeboronation for Radiolabeling Applications, Org. Lett., 2019, 21, 2488-2492. DOI:10.1021/acs.orglett.9b00942. Article was featured on the Organic Chemistry Portal.

OL GA

A. H. Harkiss, J. D. Bell, A. Knuhtsen, A. G. Jamieson and A. Sutherland, Synthesis and Fluorescent Properties of β-Pyridyl α-Amino Acids, J. Org. Chem., 2019, 84, 2879-2890. DOI:10.1021/acs.joc.9b00036. Article was featured on the Organic Chemistry Portal.

Pyridines GA

M. C. Henry, H. M. Senn and A. Sutherland, Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation, J. Org. Chem., 2019, 84, 346-364. DOI:10.1021/acs.joc.8b02888.

C-N Heterocyclisation

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2019, 36, 258-262, 556-560, 850-854, 1039-1043, 1378-1382, 1614-1618.

GA2019

2018

R. J. Faggyas, M. Grace, L. Williams and A. Sutherland, Multibond Forming Tandem Reactions of Anilines via Stable Aryl Diazonium Salts: One-Pot Synthesis of 3,4-Dihydroquinolin-2-ones, J. Org. Chem., 2018, 83, 12595-12608.  DOI:10.1021/acs.joc.8b01910.

Quinolinones GA

J. D. Bell, A. H. Harkiss, C. R. Wellaway and A. Sutherland, Stereoeselective Synthesis of 2,6-trans-4-Oxopiperidines using an Acid-Mediated 6-endo-trig Cyclisation, Org. Biomol. Chem., 2018, 16, 6410-6422.  DOI:10.1039/C8OB01363B. Front Cover of Journal. Article was selected for the themed collections: "Synthetic Methodology in OBC" and "Organic and Biomolecular Chemistry HOT article collection."

Myrtine GA

K. M. O’Rourke, E. S. Johnstone, H. M. Becker, S. L. Pimlott and A. Sutherland, Exploring the Functionalisation of the Thieno[2,3-d]pyrimidinedione Core: Late Stage Access to Highly Substituted 5-Carboxamide-6-Aryl Scaffolds, Tetrahedron, 2018, 74, 4086-4094. DOI:10.1016/j.tet.2018.06.019.

Thiophene

F. Zmuda, A. Blair, M. C. Liuzzi, G. Malviya, A. J. Chalmers, D. Lewis, A. Sutherland and S. L. Pimlott, An 18F-labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent, J. Med. Chem. 2018, 61, 4103-4114. DOI:10.1021/acs.jmedchem.8b00138.

PARP2 GA

E. K. Gibson, J. Callison, J. M. Winfield, A. Sutherland, R. H. Carr, A. Eaglesham, S. F. Parker and D. Lennon, Spectroscopic Characterisation of Model Compounds, Reactants and Byproducts Connected with an Isocyanate Production Chain, Ind. Eng. Chem. Res., 2018, 57, 7355-7362. DOI:10.1021/acs.icer.8b00853.

Amines


S. Webster, K. M. O'Rourke, C. Fletcher, S. L. Pimlott, A. Sutherland and A.-L. Lee, Rapid Iododeboronation with and without Gold Catalysis: Application to Radiolabelling of Arenes, Chem. Eur. J., 2018, 24, 937-943. DOI:10.1002/chem.201704534. Highlighted in Synfacts (2018, 14, 365).

Gold Iodine

A. H. Harkiss and A. Sutherland, Access to 2,6-Disubstituted 4-Oxopiperidines Using a 6-endo-trig Cyclization: Stereoselective Synthesis of Spruce Alkaloid and (+)-241D, J. Org. Chem., 2018, 83, 535-542. DOI:10.1021/acs.joc.7b02799.

Spruce GA

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2018, 35, 132-136, 298-302, 496-500, 702-706, 1024-1028, 1236-1240.

HOTP 2018


2017

N. L. Sloan, S. K. Luthra, G. McRobbie, S. L. Pimlott and A. Sutherland, Late Stage Iodination of Biologically Active Amines using a One-Pot Process from Aryl Amines, RSC Adv., 2017, 7, 54881-54891. DOI:10.1039/c7ra11860k. Highlighted in Synfacts (2018, 14, 321).

RSC Adv Graph Abs

R. J. Faggyas, E. D. D. Calder, C. Wilson and A. Sutherland, One-Pot Asymmetric Synthesis of Alkylidene 1-Alkylindan-1-ols using Brønsted Acid and Palladium Catalysis, J. Org. Chem., 2017, 82, 11585-11593. DOI:10.1021/acs.joc.7b02287.

Indanols GA

N. L. Sloan, S. K. Luthra, G. McRobbie, S. L. Pimlott and A. Sutherland, A One-Pot Radioiodination of Aryl Amines via Stable Diazonium Salts: Preparation of 125I-Imaging Agents, Chem. Commun., 2017, 53,  11008-11011. DOI:10.1039/C7CC06211G.

Diazo CC Graph

M. C. Henry, M. A. B. Mostafa and A. Sutherland, Recent Advances in Transition-Metal-Catalyzed, Directed Aryl C-H/N-H Cross-Coupling Reactions, Synthesis, 2017, 49, 4586-4598. DOI:10.1055/s-0036-1588536.. (Invited Submission).

Synth2 Rev

M. A. B. Mostafa, R. M. Bowley, D. T. Racys, M. C. Henry and A. Sutherland, Iron(III)-Catalyzed Chlorination of Activated Arenes, J. Org. Chem. 2017, 82, 7529-7537. DOI:10.1021/acs.joc.7b01225.

JOC Chloro GA

M. A. B. Mostafa, A. E. McMillan and A. Sutherland, Structural Diversification of the Aminobicyclo[4.3.0]nonane Skeleton Using Alkynylsilyl-derived Allylic Trichloroacetimidates, Org. Biomol. Chem., 2017, 15, 3035-3045. DOI:10.1039/C7OB00456G.

OBCSi Graph Abstr

M. A. B. Mostafa, E. D. D. Calder, D. T. Racys and A. Sutherland, Intermolecular Aryl C-H Amination Using Sequential Iron and Copper Catalysis, Chem. Eur. J., 2017, 23, 1044-1047. DOI:10.1002/chem.201605671.

CN Graph

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2017, 34, 130-134, 338-342, 566-570, 940-944, 1180-1184, 1340-1344.

GA2107


2016

S. A. I. Sharif, E. D. D. Calder, A. H. Harkiss, M. Maduro and A. Sutherland, Synthesis of Allylic Amide Functionalized 2H-Chromenes and Coumarins Using a One-Pot Overman Rearrangement and Gold(I)-Catalyzed Hydroarylation, J. Org. Chem., 2016, 81, 9810-9819. DOI: 10.1021/acs.joc.6b01881.

Chromenes

A. H. Harkiss and A. Sutherland, Recent Advances in the Synthesis and Application of Fluorescent α-Amino Acids, Org. Biomol. Chem., 2016, 14, 8911-8921. DOI:10.1039/C6OB01715K. (Invited Submission).

Graph
                        Abst

S. A. I. Sharif, E. D. D. Calder, F. G. Delolo and A. Sutherland, Synthesis of 5-Amino-2,5-dihydro-1H-benzo[b]azepines Using a One-Pot Multibond Forming Process, J. Org. Chem., 2016, 81, 6697-6706. DOI:10.1021/acs.joc.6b01357.

Benzazepines

N. L. Sloan and A. Sutherland, Recent Advances in Transition-Metal-Catalyzed Iodination of Arenes, Synthesis, 2016, 48, 2969-2980. DOI:10.1055/s-0035-1562439. (Invited Submission).

Iodination of Arenes

M. A. B. Mostafa, M. W. Grafton, C. Wilson and A. Sutherland, A One-Pot, Three-Step Process for the Diastereoselective Synthesis of Aminobicyclo[4.3.0]nonanes using Consecutive Palladium(II)- and Ruthenium(II)-Catalysis, Org. Biomol. Chem., 2016, 14, 3284-3297. DOI:10.1039/C6OB00165C.

Two Cat

D. T. Racys, S. A. I. Sharif, S. L. Pimlott and A. Sutherland, Silver(I)-Catalyzed Iodination of Arenes: Tuning the Lewis Acidity of N-Iodosucinimide Activation, J. Org. Chem., 2016, 81, 772-780. DOI:10.1021/acs.joc.5b02761. Featured Article. (Highlighted in the Organic Chemistry Portal).

Silver GA

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2016, 33, 122-126, 530-534, 742-746, 915-919, 1126-1130, 1352-1356.

GA2016


2015

F. Zmuda, G. Malviya, A. Blair, M. Boyd, A. J. Chalmers, A. Sutherland and S. L. Pimlott, Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose)polymerase-1 (PARP-1) in Vivo, J. Med. Chem., 2015, 58, 8683-8693. DOI:10.1021/acs.jmedchem.5b01324.

JMC GA

D. T. Racys, C. E. Warrilow, S. L. Pimlott and A. Sutherland, Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide, Org. Lett., 2015, 17, 4782-4785. DOI:10.1021/acs.orglett.5b02345. (Highlighted in the Organic Chemistry Portal).

Iodination
            Reaction

A. Blair, F. Zmuda, G. Malviya, A. A. S. Tavares, G. D. Tamagnan, A. J. Chalmers, D. Dewar, S. L. Pimlott and A. Sutherland, A Novel 18F-Labelled High Affinity Agent for PET Imaging of the Translocator Protein, Chem. Sci., 2015, 6, 4772-4777. DOI:10.1039/C5SC01647A. Highlighted in Chemistry and Industry.

Abstract


E. D. D. Calder and A. Sutherland, Enantioselective Synthesis of 3-Methyleneindan-1-ols via a One-Pot Allylboration-Heck Reaction of 2-Bromobenzaldehydes, Org. Lett., 2015, 17, 2514-2517. DOI:10.1021/acs.orglett.5b01047.

Indenols

E. D. D. Calder, S. A. I. Sharif, F. I. McGonagle and A. Sutherland, One-Pot Synthesis of 5-Amino-2,5-Dihydro-1-Benzoxepines: Access to Pharmacologically Active Heterocyclic Scaffolds, J. Org. Chem., 2015, 80, 4683-4696. DOI:10.1021/acs.joc.5b00583.

Benzo GA

L. Gilfillan, R. Artschwager, A. H. Harkiss, R. M. J. Liskamp and A. Sutherland, Synthesis of Pyrazole Containing α-Amino Acids via a Highly Regioselective Condensation/Aza-Michael Reaction of β-Aryl α,β-Unsaturated Ketones, Org. Biomol. Chem., 2015, 13, 4514-4523. DOI:10.1039/C5OB00364D.

Pyrazoles Amino
            Acid

C. M. Reid, K. N. Fanning, L. S. Fowler and A. Sutherland, Synthesis and Reactivity of 4-Oxo-5-trimethylsilanyl Derived α-Amino Acids, Tetrahedron, 2015, 71, 245-251. DOI:10.1016/j.tet.2014.11.059.

Silicon Amino Acids

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2015, 32, 111-115, 512-516, 760-764, 1165-1169, 1364-1368, 1612-1616.

GA2015


2014

E. D. D. Calder, F. I. McGonagle, A. H. Harkiss, G. A. McGonagle and A. Sutherland, Preparation of Amino-Substituted Indenes and 1,4-Dihydronaphthalenes Using a One-Pot Multi-Reaction Approach: Total Synthesis of Oxybenzo[c]phenanthridine Alkaloids, J. Org. Chem., 2014, 79, 7633-7648. DOI:10.1021/jo5014492.

Oxybenophenanthridines


M. W. Grafton, S. A. Johnson, L. J. Farrugia and A. Sutherland, Diastereoselective Synthesis of Highly Substituted Polycyclic Scaffolds via a One-Pot Four-Step Tandem Catalytic Process, Tetrahedron, 2014, 70, 7133-7141. DOI:10.1016/j.tet.2014.06.020. Special issue in memory of Professor Sandy McKillop.

Tandem Cat


E. D. D. Calder, M. W. Grafton and A. Sutherland, One-Pot Multi-Reaction Processes: Synthesis of Natural Products and Drug-Like Scaffolds, Synlett, 2014, 25, 1068-1080. DOI:10.1055/s-0033-1340683. Research Account.

Synlett PA

A. M. Zaed, M. W. Grafton, S. Ahmad and A. Sutherland, Asymmetric Synthesis of cis-Aminocyclopentenols, Building Blocks for Medicinal Chemistry, J. Org. Chem., 2014, 79, 1511-1515. DOI:10.1021/jo402712r.


Cyclopent

R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2014, 31, 148-153, 414-418, 706-710, 1083-1087, 1242-1246, 1671-1675.

GA2014


2013


A. Blair, L. Stevenson, D. Dewar, S. L. Pimlott and A. Sutherland, Structure-Activity Relationships of Novel Iodinated Quinoline-2-carboxamides for Targeting the Translocator Protein, Med. Chem. Commun, 2013, 4, 1461-1466. DOI: 10.1039/C3MD00249G.

SAR of TSPO

E. D. D. Calder, A. M. Zaed and A. Sutherland, Preparation of anti-Vicinal Amino Alcohols: Asymmetric Synthesis of D-erythyro-Sphinganine, (+)-Spisulosine and D-ribo-Phytosphingosine, J. Org. Chem., 2013, 78, 7223-7233. DOI:10.1021/jo401211j.

JOC1

M. W. Grafton, L. J. Farrugia and A. Sutherland, Synthesis of Substituted Indanes and Tetralins via Consecutive Multi-Bond Forming Tandem Processes, J. Org. Chem., 2013, 78, 7199-7207. DOI:10.1021/jo401182r
JOC2    
tBu

A. A. Cant, S. Champion, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Mediated Radioiodination of Aryl and Heteroaryl Bromides: Rapid Synthesis of Tracers for SPECT Imaging, Angew. Chem. Int. Ed., 2013, 52, 7829-7832. DOI: 10.1002/anie.201302800

Radioiodination


L. Gilfillan, A. Blair, B. J. Morris, J. A. Pratt, L. Schweiger, S. Pimlott and A. Sutherland, Synthesis and Biological Evaluation of Novel 2,3-Dihydro-1H-1,5-benzodiazepin-2-ones; Potential Imaging Agents of the Metabotropic Glutamate 2 Receptor, Med. Chem. Commun., 2013, 4, 1118-1123. DOI: 10.1039/C3MD00110E.

MCC1


R. A. Hill and A. Sutherland, Hot off the Press, Nat. Prod. Rep., 2013, 30, 213-217, 485-489, 760-764, 1074-1078, 1272-1276, 1462-1466.

GA2013


2012

M. Daly, A. A. Cant, L. S. Fowler, G. L. Simpson, H. M. Senn and A. Sutherland, Switching the Stereochemical Outcome of 6-Endo-Trig Cyclizations; Synthesis of 2,6-Cis-6-Substituted 4-Oxopipecolic Acids, J. Org. Chem., 2012, 77, 10001-10009. Featured Article. DOI: 10.1021/jo3022583

JOC3

S. Ahmad and A. Sutherland, Stereoselective Synthesis of Hydroxylated 3-Aminoazepanes Using a Multi-Bond Forming, Three-Step Tandem Process, Org. Biomol. Chem., 2012, 10, 8251-8259. DOI: 10.1039/C2OB26544C

OBC1

M. W. Grafton, L. J. Farrugia, H. M. Senn and A. Sutherland, Discovery Of A Multi-Bond Forming, Four-Step Tandem Process: Construction Of Drug-Like Polycyclic Scaffolds, Chem. Commun., 2012, 48, 7994-7996. DOI:10.1039/C2CC33649A
CC(Mark)   
Mark2
Mark1

A. A. S. Tavares, N. K. Jobson, D. Dewar, A. Sutherland, S. L. Pimlott, J. Batis, O. Barret, J. Seibyl and G. Tamagnan, Iodine-123 Labelled Reboxetine Analogues For Imaging Of Noradrenaline Transporter In Brain Using Single Photon Emission Computed Tomography, Synapse, 2012, 66, 923-930. DOI: 10.1002/syn.21585

Synapse 1

A. Blair, L. Stevenson and A. Sutherland, Synthesis Of The Isoquinoline Alkaloid, Crispine C, Tetrahedron Lett., 2012, 53, 4084-4086. DOI: j.tetlet.2012.05.113

TL1

A. A. Cant, R. Bhalla, S. L. Pimlott and A. Sutherland, Nickel-Catalysed Aromatic Finkelstein Reaction Of Aryl and Heteroaryl Bromides, Chem. Commun., 2012, 48, 3993-3995. DOI: 10.1039/C2CC30956D

CC(AC)

S. Ahmad, M. D. Swift, L. J. Farrugia, H. M. Senn and A. Sutherland, Stereoselective Synthesis Of Functionalised Carbocyclic Amides; Construction Of The syn-(4aS,10bS)-Phenanthridone Skeleton, Org. Biomol. Chem., 2012, 10, 3937-3945. DOI: 10.1039/C2OB25334H
Sajjad(Phen)    
SA1

A. A. Cant and A. Sutherland, Asymmetric Synthesis Of Pipecolic Acid And Derivatives, Synthesis, 2012, 44, 1935-1950. Invited Review. DOI: 10.1055/s-0031-1289767

Synthesis

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2012, 29, 129-133, 435-439, 617-621, 829-833, 1033-1037, 1377-1381.

GA2012


2011


A. Zaed and A. Sutherland, Total Synthesis Of Clavaminol A, C and H, Org. Biomol. Chem., 2011, 9, 8030-8037. DOI: 10.1039/C1OB06060K

AZ(OBC) 
 Cover
 
M. Daly, K. Gill, M. Sime, G. L. Simpson and A. Sutherland, A New General Approach For The Stereocontrolled Synthesis Of Functionalised γ- and δ-lactams, Org. Biomol. Chem., 2011, 9, 6761-6770. DOI: 10.1039/C1OB05833A

OBC MD

L. S. Fowler, L. H. Thomas, D. Ellis and A. Sutherland, A One-Pot, Reductive Amination/6-endo-trig Cyclisation For The Stereoselective Synthesis Of 6-Substituted-4-Oxopipecolic Acids, Chem. Commun., 2011, 47, 6569-6571. DOI: 10.1039/C1CC11916H
CC(LSF)   
LSF(X)

S. Ahmad, L. H. Thomas and A. Sutherland, Stereoselective Synthesis Of Polyhydroxylated Aminocyclohexanes, Org. Biomol. Chem., 2011, 9, 2801-2808. DOI: 10.1039/C0OB00619J
SA8   
SA45
F. I. McGonagle, L. Brown, A. Cooke and A. Sutherland, Microwave-Promoted Tandem Reactions For The Synthesis Of Bicyclic γ-Lactams, Tetrahedron Lett., 2011, 52, 2330-2332. DOI: 10.1016/j.tetlet.2011.02.089

TL FIM

A. A. S. Tavares, N. K. Jobson, D. Dewar, A. Sutherland and S. Pimlott, 123I-NKJ64: A Novel SPECT Radiotracer For Imaging The Noradrenaline Transporter In Brain, Synapse, 2011, 65, 658-667. DOI: 10.1002/syn.20895

Synapse 2

L. S. Fowler and A. Sutherland, Product Class 6: Acyclic And Semicyclic O/O Acetals, In Science Of Synthesis Knowledge Updates, D. J. Procter, G. A. Molander, Eds.; Thieme: Stuttgart, 2011, Vol. 2010/3, Section 29.6.2, p 121-150.

SOS

A. A. S. Tavares, N. K. Jobson, D. Dewar, A. Sutherland and S. Pimlott, Development Of The Radiosynthesis Of High-Specific-Activity 123I-NKJ64, Nucl. Med. Biol., 2011, 38, 493-500. DOI: 10.1016/j.nucmedbio.2010.11.011

NMB1

S. L. Pimlott and A. Sutherland, Molecular Tracers For The PET And SPECT Imaging Of Disease, Chem. Soc. Rev., 2011, 40, 149-162. DOI: 10.1039/B922628C

CSR

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2011, 28, 182-185, 659-662, 1031-1034, 1345-1349, 1621-1625, 1879-1882.

GA2011


2010


A. R. Kennedy, W. J. Kerr, L. C. Paterson and A. Sutherland, A Tetrahydropentaleno[1,6a-a]naphthalen-4(2H)-one Of Defined Relative Stereochemistry For Use Towards Agariblazeispirol C, Acta Cryst., 2010, C66, o473-o474. DOI: 10.1107/S0108270110031781

Acta

A. M. Zaed and A. Sutherland, Stereoselective Synthesis Of The Bicyclic Guanidine Alkaloid (+)-Monanchorin, Org. Biomol. Chem., 2010, 8, 4394-4399. DOI: 10.1039/C0OB00219D

OBC Mona

L. J. Drummond and A. Sutherland, Asymmetric Synthesis Of Allylic Secondary Alcohols: A New General Approach For The Preparation of α-Amino Acids, Tetrahedron, 2010, 66, 5349-5356. DOI: 10.1016/j.tet.2010.05.066

Tetra(LJD)

F. I. McGonagle, L. Brown, A. Cooke and A. Sutherland, A Three-Step Tandem Process For The Synthesis Of Bicyclic γ-Lactams, Org. Biomol. Chem., 2010, 8, 3418-3425. DOI: 10.1039/C004695G
OBC(FIM)   
Lactam(Cov)
L. Stevenson, A. A. S. Tavares, A. Brunet, F. I. McGonagle, D. Dewar, S. L. Pimlott and A. Sutherland, New Iodinated Quinoline-2-Carboxamides For SPECT Imaging Of The Translocator Protein, Bioorg. Med. Chem. Lett., 2010, 20, 954-957. DOI: 10.1016/j.bmcl.2009.12.061
BMCL(LS)

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2010, 27, 149-152, 477-480, 805-808, 1110-1113, 1381-1385, 1733-1736.

GA2010


2009

L. S. Fowler, D. Ellis and A. Sutherland, Synthesis Of Fluorescent Enone Derived α-Amino Acids, Org. Biomol. Chem., 2009, 7, 4309-4316. DOI: 10.1039/B912782H

OBC(LF)

C. M. Reid and A. Sutherland, Synthesis Of Isotopically Labeled α-Amino Acids, Chapter 11 In Volume 1 Of Amino Acids, Peptides And Proteins In Organic Chemistry, Ed., A. B. Hughes, Wiley-VCH, Weinheim, 2009.

Amino
              Acids

N. K. Jobson, A. R. Crawford, D. Dewar, S. L. Pimlott and A. Sutherland, Design And Synthesis Of (2R,3S)-Iodoreboxetine Analogues For SPECT Imaging Of The Noradrenaline Transporter, Bioorg. Med. Chem. Lett., 2009, 19, 4996-4998. DOI: 10.1016/j.bmcl.2009.07.064

BMCL
              (Rebo)

A. M. Zaed, M. D. Swift and A. Sutherland, A Stereoselective Synthesis Of (+)-Physoperuvine Using A Tandem Aza-Claisen Rearrangement And Ring Closing Metathesis Reaction, Org. Biomol. Chem., 2009, 7, 2678-2680. DOI: 10.1039/B907341H

OBC(Physo)   
Physo(Cover)


M. D. Swift, A. Donaldson and A. Sutherland, Tandem Aza-Claisen Rearrangement And Ring Closing Metathesis Reactions: The Stereoselective Synthesis Of Functionalised Carbocyclic Amides, Tetrahedron Lett., 2009, 50, 3241-3244. Invited contribution to a special 50th anniversary issue. DOI: 10.1016/j.tetlet.2009.02.032

TL Special Issue

R. A. Hill and A. Sutherland, Hot Off The Press,
Nat. Prod. Rep., 2009, 26, 151-154, 461-464, 725-728, 973-976, 1229-1233, 1517-1520.

GA2009


2008

C. M. Reid, C. Ebikeme, M. P. Barrett, E.-M. Patzewitz, S. Muller, D. J. Robins and A. Sutherland, Synthesis Of Novel Benzamidine- And Guanidine-Derived Polyazamacrocycles: Selective Anti-Protozoal Activity For Human African Trypanosomiasis, Bioorg. Med. Chem. Lett., 2008, 18, 5399-5401. DOI: 10.1016/j.bmcl.2008.09.047

BMCL
              CR1

N. K. Jobson, A. R. Crawford, D. Dewar, S. L. Pimlott and A. Sutherland, New Iodoreboxetine Analogues For SPECT Imaging Of The Noradrenaline Transporter, Bioorg. Med. Chem. Lett., 2008, 18, 4940-4943. DOI: 10.1016/j.bmcl.2008.08.041
BMCL
              (rebo2)

M. D. Swift and A. Sutherland, Studies On The aza-Claisen Rearrangement of 4,5-Dihydroxylated Allylic Trichloroacetimidates: The Stereoselective Synthesis Of (2R,3S)- And (2S,3S)-2-Amino-3,4-Dihydroxybutyric Acids, Tetrahedron, 2008, 64, 9521-9527. DOI: 10.1016/j.tet.2008.07.062

Tetra
              (Dihydroxy)

N. K. Jobson, R. Spike, A. R. Crawford, D. Dewar, S. L. Pimlott and A. Sutherland, Stereoselective Synthesis of (2
S,3R)- and (2R,3S)-iodoreboxetine; Potential SPECT Imaging Agents For The Noradrenaline Transporter, Org. Biomol. Chem., 2008, 6, 2369-2376. DOI: 10.1039/B802819B

OBC
              (Rebo)

S. L. Pimlott, L. Stevenson, D. J. Wyper and A. Sutherland, Rapid And Efficient Radiosynthesis of [123I]-I-PK11195, A SPECT Tracer For The Peripheral Benzodiazepine Receptors, Nucl. Med. Biol., 2008, 35, 537-542. DOI: 10.1016/j.nucmedbio.2008.02.013

NMB
              (LS)

C. M. Reid, C. Ebikeme, M. P. Barrett, E.-M. Patzewitz, S. Muller, D. J. Robins and A. Sutherland, Synthesis And Anti-protozoal Activity Of C2-Substituted Polyazamacrocycles, Bioorg. Med. Chem. Lett., 2008, 18, 2455-2458. DOI: 10.1016/j.bmcl.2008.02.037
BMCL
              CR2

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2008, 25, 11-14, 216-219, 443-446, 647-650, 841-844, 997-1000.

GA2008


2007

M. D. Swift and A. Sutherland, A Tandem Aza-Claisen Rearrangement And Ring Closing Metathesis Reaction For The Synthesis of Cyclic Allylic Trichloroacetamides, Org. Lett., 2007, 9, 5239-5242. DOI: 10.1021/ol702299c

OL
              (Tand)

K. N. Fanning and A. Sutherland, A Facile Synthesis of (S)-Gizzerosine, A Potent Agonist Of The Histamine H2-Receptor, Tetrahedron Lett., 2007, 48, 8479-8481. DOI: 10.1016/j.tetlet.2007.09.165

TL
              (Gizzerosine)

J. M. Wilson, F. Giordani, L. J. Farugia, M. P. Barrett, D. J. Robins and A. Sutherland, Synthesis, Characterisation and Anti-Protozoal Activity Of Carbamate-Derived Polyazamacrocycles, Org. Biomol. Chem., 2007, 5, 3651-3656. DOI: 10.1039/B710487A

OBC(Carb)    
JennyX


L. Stevenson, S. L. Pimlott and A. Sutherland, A Novel Approach For The Synthesis Of The Peripheral Benzodiazepine Receptor Ligand, PK11195, Tetrahedron Lett., 2007, 48, 7137-7139. DOI: 10.1016/j.tetlet.2007.07.203

TL (PK11195)

R. Bischoff, D. J. Hamilton, N. K. Jobson and A. Sutherland, New Approaches For The Synthesis Of Isotopically Labelled Guanidine-Derived Amino Acids and Noradrenaline Reuptake Inhibitors, J. Labelled Compds. Radiopharm., 2007, 50, 323-326. DOI: 10.1002/jlcr.1242

JLCRP

M. D. Swift and A. Sutherland, A Stereoselective Synthesis of (2R,3S)-2-Amino-3,4-Dihydroxybutyric Acid Using An Ether Directed aza-Claisen Rearrangement, Tetrahedron Lett., 2007, 48, 3771-3773. DOI: 10.1016/j.tetlet.2007.03.161

TL(Dihy)

A. G. Jamieson and A. Sutherland, Ether-Directed, Stereoselective Aza-Claisen Rearrangements: Synthesis Of The Piperidine Alkaloid, α-Conhydrine, Org. Lett., 2007, 9, 1609-1611. DOI: 10.1021/ol070424z

OL(Con)

A. G. Jamieson and A. Sutherland, Ether-Directed Palladium(II)-Catalysed Aza-Claisen Rearrangements: Studies On The Origin Of The Directing Effect, Tetrahedron, 2007, 63, 2123-2131. DOI: 10.1016/j.tet.2006.12.067

Tetra(Scope)

J. M. Wilson, G. Henderson, F. Black, A. Sutherland, R. L. Ludwig, K. H. Vousden and D. J. Robins, Synthesis of 5-Deazaflavin Derivatives And Their Activation Of p53 in Cells, Bioorg. Med. Chem., 2007, 15, 77-86. DOI: 10.1039/b710487a
P53

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2007, 24, 14-17, 263-266, 500-503, 655-658, 927-930, 1207-1210.

GA2007


2006

M. D. Swift and A. Sutherland, Stereocontrol Of Palladium(II)-Catalysed aza-Claisen Rearrangements Using A Combination Of 1,3-Allylic Strain And A Solvent Mediated Directing Effect, Org. Biomol. Chem., 2006, 4, 3889-3891. DOI: 10.1039/B613271E

OBC(Nor)

A. G. Jamieson and A. Sutherland, Scope And Limitations Of Ether-Directed, Metal-Catalysed aza-Claisen Rearrangements; Improved Stereoselectivity Using Non-coordinating Solvents, Org. Biomol. Chem., 2006, 4, 2932-2937. DOI: 10.1039/B607014K

OBC(Scope)


K. N. Fanning, A. G. Jamieson and A. Sutherland, Palladium(II)-Catalysed Rearrangement Reactions, Curr. Org. Chem., 2006, 10, 1007-1020.

COC

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2006, 23, 11-14, 143-146, 343-346, 513-516, 669-672, 841-844.

GA2006


2005

K. N. Fanning, A. G. Jamieson and A. Sutherland, Stereoselective β-Hydroxy-α-Amino Acid Synthesis Via An Ether Directed, Palladium Catalysed, aza-Claisen Rearrangement, Org. Biomol. Chem., 2005, 3, 3749-3756. DOI: 10.1039/B510808J

OBC(AA)


R. Bischoff, N. McDonald and A. Sutherland, A Highly Efficient, Asymmetric Synthesis Of Blastidic Acid: The β-Amino Acid Component Of The Antibiotic, (+)-Blasticidin S, Tetrahedron Lett., 2005, 46, 7147-7149. DOI: 10.1016/j.tetlet.2005.08.096

TL(Blast)


A. G. Jamieson and A. Sutherland, A Highly Stereoselective Ether Directed Palladium Catalysed Aza-Claisen Rearrangement, Org. Biomol. Chem., 2005, 3, 735-736. DOI: 10.1039/B501346C

OBC(Direct)

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2005, 22, 11-14, 141-143, 320-323, 436-438, 559-562, 668-671.

GA2005


2004

D. J. Hamilton and A. Sutherland, A Flexible Approach For The Synthesis Of Selectively Labelled L-Arginine, Tetrahedron Lett., 2004, 45, 5739-5741. DOI: 10.1016/j.tetlet.2004.05.096

TL(Arg)


A. G. Jamieson, A. Sutherland and C. L. Willis, The First Enantioselective Synthesis Of The Amino Acid, (2S,3S,4R)-γ-hydroxyisoleucine Using a Palladium(II) Catalysed 3,3-Sigmatropic Rearrangement, Org. Biomol. Chem., 2004, 2, 808-809. DOI: 10.1039/B401076K

OBC(Leu)

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2004, 21, H1-H4, H5-H8, H9-H12, H13-H15, H17-H21, H23-H26.

GA2004


PhD and Post-Doctoral Publications
2007

B. Pillai, M. Cherney, C. M. Diaper, A. Sutherland, J. S. Blanchard, J. C. Vederas and M. N. G. James, Dynamics of Catalysis Revealed From Crystal Structures of Mutants of Diaminopimelate Epimerase, Biochem. Biophys. Res. Commun., 2007, 363, 547-553. DOI: 10.1016/j.bbrc.2007.09.012

BBRC


2006


B. Pillai, M. M. Cherney, C. M. Diaper, A. Sutherland, J. S. Blanchard, J. C. Vederas and M. N. G. James, Structural Insights Into Stereochemical Inversion By Diaminopimelate Epimerase: An Antibacterial Drug Target, Proc. Natl. Acad. Sci. USA, 2006, 103, 8668-8673. DOI: 10.1073/pnas.0602537103

PNAS


2005

C. M. Diaper, A. Sutherland, B. Pillai, M. N. G. James, P. Semchuk, J. S. Blanchard and J. C. Vederas, The Stereoselective Synthesis Of Aziridine Analogues Of Diaminopimelic Acid (DAP) And Their Interaction With DAP Epimerase, Org. Biomol. Chem., 2005, 3, 4402-4411. DOI: 10.1039/B513409A
OBC(Azi)    
Azi(Cov)


2003

G. Karig, J. M. Large, C. G. V. Sharples, A. Sutherland, T. Gallagher and S. Wonnacott, Synthesis and Nicotinic Binding Of Novel Phenyl Derivatives Of UB-165. Identifying Factors Associated with α-7 Selectivity, Bioorg. Med. Chem. Lett., 2003, 13, 2825-2828. DOI: 10.1016/S0960-894X(03)00594-8

BMCL(UB165)

A. Sutherland and T. Gallagher, The Synthesis And Reactivity Of Halopyridylboronic Acids, Reactivity, 2003, 4-7.

React


A. Sutherland and T. Gallagher, Versatile Synthesis Of 3,5-Disubstituted 2-Fluoropyridines And 2-Pyridones, J. Org. Chem., 2003, 68, 3352-3355. DOI: 10.1021/jo026864f

JOC(Py)


A. Sutherland, T. Gallagher, C. G. V. Sharples and S. Wonnacott; The Synthesis Of Two Fluoro Analogues Of The Nicotinic Acetylcholine Receptor Agonist UB-165,
J. Org. Chem., 2003, 68, 2475-2478. DOI: 10.1021/jo026698b
JOC(F)

R. A. Hill and A. Sutherland, Hot Off The Press, Nat. Prod. Rep., 2003, 20, xlv-xlviii.
 

2002

A. Sutherland and J. C. Vederas, Conjugate Addition Of Radicals Generated From Diacyloxyiodobenzenes to Dehydroamino Acid Derivatives; A Synthesis of Diaminopimelic Acid Analogues, Chem. Commun., 2002, 224-225. DOI: 10.1039/B109343F

CC(Rad)


2001 

J. F. Caplan, A. Sutherland and J. C. Vederas, The First Stereospecific Synthesis of L-Tetrahydrodipicolinic Acid; A Key Intermediate Of Diaminopimelate Metabolism, J. Chem. Soc., Perkin Trans. 1, 2001, 2217-2220. DOI: 10.1039/B105091P
Perkin(THDP2)
 

A. Sutherland, K. Auclair and J. C. Vederas, Recent Advances In The Biosynthetic Studies Of Lovastatin,
Current Opinion in Drug Discovery and Development, 2001, 4, 229-236.

Cur(Lov)
 

2000

K. Auclair, A. Sutherland, J. Kennedy, D. J. Witter, J. P. Van den Heever, C. R. Hutchinson and J. C. Vederas, Lovastatin Nonaketide Synthase Catalyses An Intramolecular Diels-Alder Reaction Of A Substrate Analogue, J. Am. Chem. Soc., 2000, 122, 11519-11520. DOI: 10.1021/ja003216+

JACS(Lov2)
 
A. Sutherland and C. L. Willis, Synthesis Of Fluorinated Amino Acids, Nat. Prod. Rep., 2000, 17, 621-631. DOI: 10.1039/A707503K

NPR(Fluoro)
 
M. Cirilli, G. Scapin, A. Sutherland, J. C. Vederas and J. S. Blanchard, The Three-Dimensional Structure Of The Ternary Complex Of Corneybacterium glutamicum Diaminopimelate Dehydrogenase-NADPH-L-2-Amino-6-Methylene-Pimelate, Protein Science, 2000, 9, 2034-2037. DOI: 10.1110/ps.9.10.2034

ProSci
 
J. R. Harding, R. A. Hughes, N. M. Kelly, A. Sutherland and C. L. Willis, Syntheses of Isotopically Labelled L-α-Amino Acids With An Asymmetric Centre at C-3, J. Chem. Soc., Perkin Trans. 1, 2000, 3406-3416. DOI: 10.1039/B005172L

Perkin(AA)
 
C. W. Koo, A. Sutherland, J. C. Vederas and J. S. Blanchard, Identification of Active Site Cysteine Residues That Function As General Bases: Diaminopimelate Epimerase, J. Am. Chem. Soc., 2000, 122, 6122-6123. DOI: 10.1021/ja001193t
JACS(Epim)
 
R. J. Cox, A. Sutherland and J. C. Vederas, Bacterial Diaminopimelate Metabolism As A Target For Antibiotic Design, Bioorg. Med. Chem., 2000, 8, 843-871. DOI: 10.1016/S0968-0896(00)00044-4

BMC(DAP)
 
G. Bhalay, S. Clough, L. McLaren, A. Sutherland and C. L. Willis, Synthesis and Enzyme-Catalysed Reductions Of 2-Oxo Acids With Oxygen Containing Side-Chains, J. Chem. Soc., Perkin Trans. 1, 2000, 901-910. DOI: 10.1039/A909677I

Perkin(LDH)
 
M. D. Fletcher, J. R. Harding, R. A. Hughes, N. M. Kelly, H. Schmalz, A. Sutherland and C. L. Willis, Three Approaches To The Synthesis Of L-Leucine Selectively Labelled With Carbon-13 Or Deuterium In Either Diastereotopic Methyl Group, J. Chem. Soc., Perkin Trans. 1, 2000, 43-52. DOI: 10.1039/A907598D

Perkin(Leu)
 

1999

A. Sutherland and J. C. Vederas, The First Isolation Of An Alkoxy-N,N-Dialkylaminodifluorosulfane From The Reaction Of An Alcohol And DAST: An Efficient Synthesis Of (2S,3R,6S)-3-Fluoro-2,6-Diaminopimelic Acid, Chem. Commun., 1999, 1739-1740. DOI: 10.1039/A904821I

CC(Fluo)
 
A. Sutherland and C. L. Willis, Synthesis Of Probes For The Active Site Of Leucine Dehydrogenase, Bioorg. Med. Chem. Lett., 1999, 9, 1941-1944. DOI: 10.1016/S0960-894X(99)00297-8

BMCL(LeuDH)
 
A. Sutherland, J. F. Caplan and J. C. Vederas, Unsaturated α-Aminopimelic Acids As Potent Inhibitors Of meso-Diaminopimelic Acid (DAP) D-Dehydrogenase, Chem. Commun., 1999, 555-556. DOI: 10.1039/A900297I

CC(DAP)
 
M. Frank, E. Kingston, J. C. Jeffery, M. O. Moss, M. Murray, T. J. Simpson and A. Sutherland, Walleminol and Walleminone, Novel Caryophyllenes From The Toxigenic Fungus Wallemia sebi, Tetrahedron Lett., 1999, 40, 133-136. DOI: 10.1016/S0040-4039(98)80039-7

TL(Wall)
 

1996-1998

A. Sutherland and C. L. Willis, Chemoenzymatic Synthesis Of 4-Amino-2-Hydroxy Acids: A Comparison Of Mutant And Wild-Type Oxidoreductases, J. Org. Chem., 1998, 63, 7764-7769. DOI: 10.1021/jo980821a

JOC(Gam)
 
M. D. Fletcher, N. M. Kelly, A. Sutherland and C. L. Willis, “EnantioselectiveSynthesis Of L-α-Amino Acids Incorporating Stable Isotopic Labels,” In “Synthesis And Applications Of Isotopically Labelled Compounds 1997,” eds. J. R. Heys and D. G. Melillo, Wiley, 1998, 161-164.
 
A. Sutherland and C. L. Willis, Synthesis Of α-Amino-β-Hydroxy Acids, [15N]-L-alloThreonine And [15N]-L-Threonine, Tetrahedron Lett., 1997, 38, 1837-1840. DOI: 10.1016/S0040-4039(97)00164-0

TL(Threo)
 
N. M. Kelly, A. Sutherland and C. L. Willis, Syntheses Of Amino Acids Incorporating Stable Isotopes, Nat. Prod. Rep., 1997, 14, 205-220. DOI: 10.1039/NP9971400205

NPR(Lab)
 
A. Sutherland and C. L. Willis, Synthesis Of [6-13C]-L-Lysine, J. Labelled Compds. Radiopharm., 1996, 38, 95-102. DOI: 10.1002/(SICI)1099-1344(199601)38:1<95::AID-JLCR816>3.0.CO;2-Q

JLCR(Lys)