The Biomolecular spectroscopy & dynamics Cluster (BioC)

The machinery of biology is amazing: nanoscale machines reading information, building new cells, transforming and storing energy, fighting against invaders, and cleaning up afterwards. These amazing machines are molecules such as proteins, DNA, and smaller molecules such as sugars and water. Biochemistry has already given us an amazing insight into this interconnected world. The next big scientific challenge is to understand and then apply the physics of these biological processes in order to control biochemical processes and create synthetic forms of life. One of the most important tools to probe these biophysical processes is biomolecular spectroscopy.

We are a group of researchers that specialise in biomolecular spectroscopy and in particular in dynamical (typically femtosecond to second) processes. Many of the techniques we develop and employ are world leading and involve femtosecond spectroscopy, single-molecule imaging, plasmonics, and many more. Our facilities allow the full range of modern biochemistry and biophysical characterisation techniques. Our group includes computer scientists specialising in simulations of molecular dynamics and quantum processes in biomolecules.

The core group at Glasgow University (Kadodwala, Kelly, Lapthorn, Magennis, Smith, and Wynne) have a portfolio of internationally leading research funded by RCUK worth £4.2M. This team is very well equipped with refurbished laser lab suites, 4 ultrafast laser systems, 5 state-of-the-art microscopes (including FLIM), NMR, CD, SPR, FTIR, etc. The group publishes widely in high impact factor journals, for example, Lapthorn, Wynne, et al., Nature Commun. 5, 3999 (2014); Kelly et al., Nature Commun. 5, 4763 (2014); Kelly, Smith, et al., Science 335, 1492 (2012); and Lapthorn, Kelly, Kadodwala, et al., Nature Nano. 5, 783 (2010).

Mosquitoes

Mosquito spectroscopy project involving Klaas Wynne (Chemistry), Dr Lisa Ranford-Cartwright(IIII, GU), Dr Heather Ferguson (IBAHCM, GU), Dr Francesco Baldini (IBAHCM, GU) – spectroscopy of mosquitoes.

Grants of core group

Period

Grant #

Title

PI
(£ FEC)

CI
(£ FEC)

Investigators

2014-2017

BBSRC
BB/L02022X/1

A novel mechanism of protein uptake in Gram-negative bacteria

 

379k

D. Walker, O. Byron, R.J. Cogdell, J. Milner, B. Smith

2014-2017

EPSRC
EP/L027003/1

From nature to nano: structure, dynamics and reactivity of DNA three-way junctions

396k

 

S.W. Magennis

2013-2016

BBSRC
BB/K00932X/1

How does the plant UV-B photoreceptor UVR8 initiate signalling?

 

394k

G.I. Jenkins, J. Christie, B. Smith

2013-2016

BBSRC
BB/K001957/1

Speeding and stuttering: analysing the dynamics of DNA replication at the single molecule level

376K

 

S.W. Magennis

2013-2016

EPSRC
EP/K034995/1

Solvation dynamics and structure around proteins and peptides: collective network motions or weak interactions

546k

 

K. Wynne, A. Lapthorn, S. Kelly

2013-2016

EPSRC
EP/K034936/1

Plasmon-Enhanced Chiroptical Biosensors

780k

 

M. Kadodwala, N. Gadegaard, G. Cooke

2013-2016

Leverhulme

Ultrasensitive characterisation of biological structure
with supertwisted ligh

162k

 

M. Kadodwala

2012-2015

EPSRC
EP/J004790
EP/J004812
EP/J014478

Liquid–liquid transitions in molecular liquids: from supramolecular structure to phase separation

664k

 

K. Wynne, J. Sefcik (J. Chapman)

2012-2015

EPSRC
EP/J00975X/1
EP/J009733/1

The structure and dynamics of water confined in nanoscale pools: the dynamic crossover

523k

 

K. Wynne, N. Hunt

 

 

 

£3447k

£773k

 

 

Also visit the web sites of the Dynamics & Structure grouping in the School of Chemistry at the University of Glasgow

WestChem

ScotCHEM

  Creative Commons License

05-Jan-2016