The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Cronin group researchers discover spontaneously assembled organic-inorganic “DNA”

Genetic material in the form of DNA and RNA is essential for life and evolution, but how did it first arise? This is a big mystery and poses a classic ‘chicken and egg’ conundrum: what type of molecule could have determined the sequence of the very molecule in which sequence is encoded? Researchers in the Cronin Group have reported an organic-inorganic compound whose structure closely resembles the naturally occurring Z-form of DNA which forms simply by mixing molybdate with GMP at low pH. It is hoped that the structure could open new avenues in the exploration of the transition between biologically inert matter and living systems.

Link to full paper

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Advanced Research Centre (ARC)
Level 5, Digital Chemistry
University of Glasgow
11 Chapel Lane
Glasgow G11 6EW
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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499. Electron density-based GPT for optimization and suggestion of host–guest binders

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498. A programmable hybrid digital chemical information processor based on the Belousov-Zhabotinsky reaction

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497. An integrated self-optimizing programmable chemical synthesis and reaction engine

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496. Autonomous execution of highly reactive chemical transformations in the Schlenkputer

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495. Universal chemical programming language for robotic synthesis repeatability

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494. Bringing digital synthesis to Mars

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493. An Autonomous Electrochemical Discovery Robot that Utilises Probabilistic Algorithms: Probing the Redox Behaviour of Inorganic Materials

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492. Reaction Kinetics using a Chemputable Framework for Data Collection and Analysis

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491. Assembly theory explains and quantifies selection and evolution

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490. Digital design and 3D printing of reactionware for on demand synthesis of high value probes


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