2020
Development of potent PfCLK3 inhibitors based on TCMDC-135051 as a new class of antimalarials
Amit Mahindra, Omar Janha, Kopano Mapesa, Ana Sanchez Azqueta, Mahmood M Alam, Alfred Amambua-Ngwa, Davies C Nwakanma, Andrew B Tobin, and Andrew G. Jamieson
J. Med. Chem. 2020
DOI: 10.1021/acs.jmedchem.0c00451
2019
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
Mahmood M. Alam, Ana Sanchez-Azqueta, Omar Janha, Erika L. Flannery, Amit Mahindra, Kopano Mapesa,
Aditya B. Char, Dev Sriranganadane, Nicolas M. B. Brancucci, Yevgeniya Antonova-Koch, Kathryn Crouch,
Nelson Victor Simwela, Scott B. Millar, Jude Akinwale, Deborah Mitcheson, Lev Solyakov, Kate Dudek,
Carolyn Jones, Cleofé Zapatero, Christian Doerig, Davis C. Nwakanma, Maria Jesús Vázquez,
Gonzalo Colmenarejo, Maria Jose Lafuente-Monasterio, Maria Luisa Leon, Paulo H. C. Godoi, Jon M. Elkins,
Andrew P. Waters, Andrew G. Jamieson, Elena Fernández Álvaro, Lisa C. Ranford-Cartwright, Matthias Marti,
Elizabeth A. Winzeler, Francisco Javier Gamo and Andrew B. Tobin
Science, 2019, 365, 6456, eaau1682
DOI: 10.1126/science.aau1682
Synthesis of HDAC Substrate Peptidomimetic Inhibitors Using Fmoc Amino Acids Incorporating Zinc-Binding Groups
Amit Mahindra, Christopher J. Millard, Iona Black, Lewis J. Archibald, John W. R. Schwabe and Andrew G. Jamieson
Organic Letters, 2019, 21, 9, 3178-3182
DOI: 10.1021/acs.orglett.9b00885
Synthesis and fluorescent properties of beta-pyridyl alpha-amino acids.
Harkiss, A. H., Bell, J. D., Knuhtsen, A., Jamieson, A. G. and Sutherland, A.
Journal of Organic Chemistry, 2019, 84, 5, 2879-2890
DOI: 10.1021/acs.joc.9b00036
Friends or foes? Emerging impacts of biological toxins.
Clark, G. C., Casewell, N. R., Elliott, C. T., Harvey, A. L., Jamieson, A. G. , Strong, P. N. and Turner, A. D.
Trends in Biochemical Sciences, 2019, 44, 4, 365-379
DOI: 10.1016/j.tibs.2018.12.004
2018
alpha-conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor
Astrid Knuhtsen, Charlotte Whitmore, Fergus S. McWhinnie, Laura McDougall, Rachel Whiting, Brian O. Smith, Christopher M. Timperley, A. Christopher Green, Kenneth I. Kinnear and Andrew G. Jamieson*
Chemical Science, 2019, 10, 1671-1676
DOI: 10.1039/C8SC04198A
Histone deacetylase (HDAC) 1 and 2 complexes regulate both histone acetylation and crotonylation in vivo.
Kelly, R.D.W., Chandru, A., Watson, P.J., Song, Y., Blades, M., Robertson, N.S., Jamieson, A.G. , Schwabe, J.W.R. and Cowley, S.M.
Scientific Reports, 2018, 8(1), 14690.
DOI: 10.1038/s41598-018-32927-9
Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus
Georgina C. Girt, Amit Mahindra, Zaaima J. H. Al Jabri, Megan De Ste Croix, Marco R. Oggionic and Andrew G. Jamieson*
Chem. Commun., 2018, Advance Article
DOI: 10.1039/C7CC06093A
Enzymatically-stable oxetane-based dipeptide hydrogels.
Laura McDougall, Emily R. Draper, Jonathan D. Beadle, Michael Shipman, Piotr Raubo, Andrew G. Jamieson* and Dave J. Adams*
Chem. Commun., 2018, 54 , 1793-1796
DOI: 10.1039/C7CC09701H
2017
Solid-phase synthesis of oxetane modified peptides.
Jonathan D. Beadle, Astrid Knuhtsen, Alex Hoose, Piotr Raubo, Andrew G. Jamieson*, and Michael Shipman*
Org. Lett., 2017, 19 (12), pp 3303–3306
DOI: 10.1021/acs.orglett.7b01466.
Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor.
Pacifico S, Kerckhoffs A, Fallow AJ, Foreman RE, Guerrini R, McDonald J, Lambert DG, Jamieson AG.
Org Biomol Chem. 2017;15(21):4704-4710.
DOI: 10.1039/c7ob00959c.
2016
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Peter J. Watson, Christopher J. Millard, Andrew M. Riley, Naomi S. Robertson, Lyndsey C. Wright, Himali Y. Godage, Shaun M. Cowley, Andrew G. Jamieson, Barry V. L. Potter & John W. R. Schwabe
Nat. Comm., 2016, 7 ,11262
DOI: 10.1038/ncomms11262.
A TPX2 proteomimetic has enhanced affinity for Aurora-A due to hydrocarbon stapling of a helix.
Yana K. Rennie†, Patrick J. McIntyre, Tito Akindele, Richard Bayliss*, and Andrew G. Jamieson*
ACS Chem. Biol., 2016, 11 (12), pp 3383–3390
DOI: 10.1021/acschembio.6b00727.
A heme-binding domain controls regulation of ATP-dependent potassium channels
Mark J. Burton, Sofia M. Kapetanaki, Tatyana Chernova, Andrew G. Jamieson, Pierre Dorlet, Jérôme Santolini, Peter C. E. Moody, John S. Mitcheson, Noel W. Davies, Ralf Schmid, Emma L. Raven and Nina M. Storey
PNAS 2016, 113 (14) 3785-3790.
DOI: 10.1073/pnas.1600211113.
2015
Regulation of protein–protein interactions using stapled peptides.
Robertson N, Jamieson A
Reports in Organic Chemistry, 2015(5), pp. 65-74.
DOI: 10.2147/ROC.S68161.
Insights into the recruitment of class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR transcriptional repression complex.
Hudson GM, Watson PJ, Fairall L, Jamieson AG, Schwabe JW.
J Biol Chem. 2015 Jul 17;290(29):18237-44.
DOI: 10.1074/jbc.M115.661058.
2014
Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained alpha-helix peptides.
Boris Aillard, Naomi S. Robertson, Adam R. Baldwin, Siobhan Robins and Andrew G. Jamieson
Org. Biomol. Chem., 2014, 12, 8775-8782
DOI: 10.1039/C4OB01832J.
The ansamycin antibiotic, Rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain.
Sian E. Evans, Benjamin T. Goult, Louise Fairall, Andrew G. Jamieson, Paul Ko Ferrigno, Robert Ford, John W. R. Schwabe, Simon D. Wagner
PLoS ONE, 9(3), e90889
DOI: 10.1371/journal.pone.0090889.
2013
Peptide scanning for studying structure-activity relationships in drug discovery.
Jamieson AG, Boutard N, Sabatino D, Lubell WD
Chem Biol Drug Des. 2013;81(1):148-65.
DOI: 10.1111/cbdd.12042..
2012
A novel dihydro-pyrazolo(3,4d)(1,2,4)triazolo(1,5a)pyrimidin-4-one (AJ23) is an antagonist at adenosine A1 receptors and enhances consolidation of step-down avoidance.
Harvey, A. L., Young, L. C., Kornisiuk, E., Snitcofsky, M., Colettis, N., Blanco, C., Jerusalinsky, D., Jamieson, A. G. , Hartley, R. C. and Stone, T. W.
Behavioural Brain Research, 234(2), pp. 184-191.
DOI: 10.1016/j.bbr.2012.06.023.
A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic.
Andrew G. Jamieson,* David Russell and Andrew D. Hamilton*
Chem. Commun., 2012,48, 3709-3711
DOI: 10.1039/C2CC30295K.
2010
Insertion of multiple α-amino γ-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns.
Luisa Ronga, Andrew G. Jamieson, Kim Beauregard, Christiane Quiniou, Sylvain Chemtob, William D. Lubell
Biopolymers, 2010, 94(2), pp. 183-191.
DOI: 10.1002/bip.21288.
Structure-activity analysis of the growth hormone Secretagogue GHRP-6 by α- and β-amino γ-lactam positional scanning.
Nicolas Boutard, Andrew G. Jamieson, Huy Ong, William D. Lubell
Chemical Biology and Drug Design, 75(1), pp. 40-50.
DOI: 10.1111/j.1747-0285.2009.00913.x.
α-Amino-β-hydroxy-γ-lactam for constraining peptide Ser and Thr residue conformation.
Daniel J. St-Cyr, Andrew G. Jamieson and William D. Lubell*
Org. Lett., 2010, 12 (8), pp 1652–1655
DOI: 10.1021/ol1000582.
2009
Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides.
Andrew G. Jamieson, Nicolas Boutard, Kim Beauregard, Mandar S. Bodas, Huy Ong, Christiane Quiniou, Sylvain Chemtob and William D. Lubell
J. Am. Chem. Soc., 2009, 131 (22), pp 7917–7927
DOI: 10.1021/ja9010628.
2007
Ether-directed palladium(II)-catalysed aza-Claisen rearrangements: studies on the origin of the directing effect.
Jamieson, A. G. and Sutherland, A.
Tetrahedron, 2007, 63, pp. 2123-2131.
DOI: 10.1016/j.tet.2006.12.067
Ether-directed, stereoselective aza-Claisen rearrangements: Synthesis of the piperidine alkaloid, alpha-conhydrine.
Jamieson, A. G. and Sutherland, A.
Organic Letters, 2007, 9, pp. 1609-1611.
DOI: 10.1021/ol070424z
2006
Palladium(II)-catalysed rearrangement reactions.
Fanning, K. N., Jamieson, A. G. and Sutherland, A.
Current Organic Chemistry, 10(9), pp. 1007-1020.
DOI: 10.2174/138527206777435490
Scope and limitations of ether-directed, metal-catalysed aza-Claisen rearrangements; improved stereoselectivity using non-coordinating solvents.
Jamieson, A. G. and Sutherland, A.
Organic and Biomolecular Chemistry, 2006, 4, pp. 2932-2937.
DOI: 10.1039/B607014K
2005
Stereoselective beta-hydroxy-alpha-amino acid synthesis via an ether-directed, palladium-catalysed aza-Claisen rearrangement.
Fanning, K. N., Jamieson, A. G. and Sutherland, A.
Organic and Biomolecular Chemistry, 3, pp. 3749-3756.
DOI: 10.1039/B510808J
A highly stereoselective ether directed palladium catalysed aza-Claisen rearrangement.
Jamieson, A. G. and Sutherland, A.
Organic and Biomolecular Chemistry, 3, pp. 735-736.
DOI: 10.1039/B501346C
2004
The first enantioselective synthesis of the amino acid, (2S,3S,4R)-gamma-hydroxyisoleucine using a palladium(II) catalysed 3,3-sigmatropic rearrangement.
Jamieson, A. G. , Sutherland, A. and Willis, C. L.
Organic and Biomolecular Chemistry, 2, pp. 808-809.
DOI: 10.1039/B401076K