Programme
"Structure Validation"
With guest speakers:
Sameer Velankar (PDBe), Gert Vriend (Radboud University Nijmegen) and Judit Debreczeni (AstraZeneca)
Tuesday 31st January
12:30 - 13:30 Lunch
Session 1:
Chair: Mads Gabrielsen (Glasgow)
14:10 - 14:25 Matthew Mold (Keele) - Structural studies of Limulus SAP
14:30 - 14:45 Kate Beckham (Glasgow) - Structural characterisation of Tpx reveals a binding site for novel antibacterial compounds
14:50 - 15:05 Paul Elliot (Liverpool) - Novel structural features within the ubiquitin specific protease family: Does the crystal ever lie?
15:10 - 15:25 Peter Moody (Leicester) - Chasing Rainbows in the Mountains
15:30 - 15:45 Helen Woodroof (Dundee) - (Early) progress towards structural characterisation of PINK1
15:45 - 16:20: Tea
Session 2:
Chair: Julie Tucker (AstraZeneca)
16:20 - 16:35 Karen McLuskey (Glasgow) - Something clever, no doubt...
16:40 - 16:55 John Chipperfield (Manchester) - Structural insights into the conformation and function of the ion channel scaffolding protein, PSD-95
17:00 - 17:15 Wenhe Zhon (Edinburgh) - The allosteric mechanism of pryuvate kinase from T.Cruzi
17:20 - 17:35 Weisha Luan (York) - The structure of Portal/TRAP fusion protein
17:40 - 17:55 Haunting Liu (St Andrews) - Structure and mechanism of an enzyme in garlic acid metabolic pathway
19:00 - 20:00 : Dinner
Chair: Peter Moody (Leicester)
20:15 - 20:30 Musadiq Ibrahim (Glasgow) - Pharmacophore and Fragment based approaches to investigate the function of Protein, TdcF
20:35 - 20:50 Miriam Walden (Leeds) - Asymmetric cell division in developing Drosophila neuroblasts
20:55 - 21:10 Thembaninkosi Grace Gaule (Leeds) - Copper amine oxidases: do the hugging monomers communicate?
Wednesday 1st September
8:00 - 9:00 Breakfast
Session 4: AstraZeneca Plenary Session
Chair: Tina Howard (AstraZeneca)
09:10 - 10:00 Sameer Velankar (PDBe) - Structure validation and deposition to PDB
10:10 - 11:00 Gert Vriend (CMBI, NCMLS, UMC Nijmegen) - The importnace of structure validation
11:10 - 11:35 Coffee
Session 5:
Chair: Paul Elliot (Liverpool)
11:40 - 12:10 Judit Debreczeni (AstraZeneca) - Practical aspects of ligand structure validation
12:20 - 12:35 Karishma Satia (Manchester) - Structural Basis of hSTRAP function
12:40 - 12:55 Paul Acklam (Leeds) - X-ray crystallographic studies of rationally designed dihydroorotate dehydrogenase inhibitors
13:00 - 13:15 Olivia Sleator (Rigaku) - The Screen Machine
13:30 - 14:30 Lunch
Free afternoon
19:00 Conference Dinner
and Karaoke
Thursday 2nd September
8:00 - 9:00 Breakfast
Session 6:
Chair: Julie Tucker (AstraZeneca)
09:05 - 09:20 Mads Gabrielsen (Glasgow) - Two of your five-a-day. Structures of lectins from Champedak
09:25 - 09:40 James Austin (Liverpool) - Structural studies of the RNA/DNA binding domains of TDP-43
09:45 - 10:00 Amanda McFeat (York) - SpoIIQ:SpoIIIAH complex, an intercompartmental channel in sporulating Bacillus subtilis
10:05 - 10:20 Neil Rustage Liverpool University A new mechanism for discrimination against carbon monoxide by haemproteins
10:30 - 11:00 Coffee
Session 7:
Chair: Karen McLuskey (Glasgow)
11:00 - 11:15 Jamie Barry (Manchester) - Structure and function of a conserved lipoprotein involved in type IV pilus biogenesis
11:20 - 11:35 Barbara Franke (Liverpool) - TBA
11:40 - 11:55 Gareth Wright (Liverpool) - Lead compound optimisation for SOD1 mediated fALS by crystallographic screening
12:00 - 12:15 Huixiang Liu (St Andrews) - A modified dual expression system for high throughput protein complex production in E. coli
12:20 - 12:35 QinQin Zhuang (John Moores) - Purification and crystallisation of Histone octamer, dimer and tetramer
12:40 Closing remarks
1:00 - 2:00 Lunch
There is no place like home.