

Robin M. Hochstrasser
( hochstra
sas.upenn.edu)
Robin is Donner Professor of Physical Sciences in the Department of Chemistry at the University of Pennsylvania in Philadelphia. He is also a visiting professor in the BCP group during 2006 and 2007.
Degrees
- 1952 Heriot-Watt University , B.Sc. (Applied Chemistry)
- 1955 University of Edinburgh, Ph.D. (Pure Chemistry)
- 1984 Heriot-Watt University, D. Sc. (Honoris causa)
Appointments
Director, Regional Laser and Biomedical Research Laboratory, University of Pennsylvania, 1978-present; Donner Professor of Physical Sciences, Department of Chemistry, University of Pennsylvania, 1983-present; Blanchard Professor, Department of Chemistry, University of Pennsylvania, 1968-1983; Professor, Department of Chemistry, University of Pennsylvania, 1967-1968; Associate Professor, Department of Chemistry, University of Pennsylvania, 1963-1967; Research Associate, Florida State University, 1960-1961; Research Associate, National Research Council of Canada, 1960-1960; Department of Chemistry, University of British Columbia, Instructor, Assistant, Professor, 1957-1963; Pilot Officer, Royal Air Force, Education Branch, 1955-1957
Other Positions, Academic and Professional
Chair of the John Scott Advisory Panel for the City of Philadelphia (1985-present); Chair of the ACS Division of Biophysical Chemistry (1998); Chair of the APS Division of Chemical Physics (1998); Visiting Professor, University of Paris (1987); Christianson Fellow, Oxford University (1982); Visiting Professor, Universitat Munchen (1980); Visiting Professor, California Institute of Technology (1975); Visiting Professor, University of Grenoble (1974, 1989); Visiting Professor, Australian National University, Canberra (1973); Visiting Professor, and Fellow of Clare College, Cambridge University, England (1972);
Selected Honors
Honorary Fellow of the Royal Society of Edinburgh (2008); Albert F. Cotton Award in Chemistry (2005); Benjamin Franklin Medal in Chemistry (2003); Centenary Silver Medal of the Royal Society of Chemistry (2000); E. Bright Wilson Award in Spectroscopy (1998); Ellis Lippincott Award of the Optical Society of America (1997); LICOR Award, University of Nebraska (1996); Peter Debye Award in Physical Chemistry(1996); National Institute of Health Merit Award (1990-2000); A.C.S. Philadelphia Section Award (1990); Optical Society of America, Fellow (1989); SPIE Special President's Award (1986); Heriot-Watt University, Scotland, D. Sc., (Ho noris Causa) (1984); Member American Academy of Arts and Sciences (1982); Member National Academy of Sciences (1982); Bourke Medal, Faraday Society (1981); Alexander von Humboldt Senior Fellow (1978); American Physical Society, Fellow (1978); Alfred P. Sloan Foundation Fellow (1963-1967); John Simon Guggenheim Fellow (1972); Courtauld Scholar (1952-1955);
Selected Lectureships
Encyclopedia Britannica Lecture, University of Chicago (1969); Sherwin-Williams Lecturer, University of Illinois, Illinois (1977); Professor Associe, University of Paris (1978); Phillips Lecturer, Haverford College (1978); FMC Lecturer, Princeton University (1979); Walter E. Kaskan Memorial Lecturer, SUNY Binghampton (1979); Bourke Lecturer, Faraday Society, Edinburgh, Birmingham, Royal Institution (1981); Grenoble Spectroscopy Lectures (1981); Distinguished Lecturer, Okazaki, Japan (September, 1981); W. A. Noyes Distinguished Lecturer, University of Texas (1982); Pew Memorial Lecturer, Widener University (1982); Sir Cyril Hinshelwood Lecturer, Oxford University (1982); Dreyfus Lecturer, University of Kansas (1986); Reilly Lecturer, Notre Dame University (1986); William Draper Harkins Lecture, University of Chicago (1990); Kolthoff Lecturer, University of Minnesota (1991); Beckman Lecturer, University of Illinois (1993); Centennial Award Lecture CUNY (1994); LICOR Award Lecture, University of Nebraska (1996); Research Frontiers in Chemistry Lectures, University of Iowa (1999); The Willard Lectures, University of Wisconsin (1999); Centenary Lecturer, Royal Society of Chemistry (2000); Pitzer Lecturer, University of California at Berkeley (2000); Gunning Lecturer, University of Alberta (2000); The Malcolm Dole Distinguished Lectures, Northwestern (2001); A.R. Gordon Distinguished Lecturer, University of Toronto (2002); Gomberg Lecture, University of Michigan (2002); Coover Lecture, Iowa State University (2002).
Recent Peer Reviewed Publications
(from a total of about 700)
- Sharonov, A; Bandichhor, R; Burgess, K; Petrescu, AD; Schroeder, F; Kier, AB; Hochstrasser, RM, Lipid diffusion from single molecules of a labeled protein undergoing dynamic association with giant unilamellar vesicles and supported bilayers, Langmuir 24, 844-850 (2008)
- Kim, YS; Liu, L; Axelsen, PH; Hochstrasser, RM, Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from A beta 40, Proc. Natl. Acad. Sci. U. S. A. 105, 7720-7725 (2008)
- Fang, C; Bauman, JD; Das, K; Remorino, A; Arnold, E; Hochstrasser, RM, Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase, Proc. Natl. Acad. Sci. U. S. A. 105, 1472-1477 (2008)
- Sharonov, A; Hochstrasser, RM, Single-molecule imaging of the association of the cell-penetrating peptide Pep-1 to model membranes, Biochemistry 46, 7963-7972 (2007)
- Kuo, CH; Hochstrasser, RM, Two dimensional infrared spectroscopy and relaxation of aqueous cyanide, Chem. Phys. 341, 21-28 (2007)
- Finikova, OS; Troxler, T; Senes, A; DeGrado, WF; Hochstrasser, RM; Vinogradov, SA, Energy and electron transfer in enhanced two-photon-absorbing systems with triplet cores, J. Phys. Chem. A 111, 6977-6990 (2007)
- Kuo, CH; Vorobyev, DY; Chen, JX; Hochstrasser, RM, Correlation of the vibrations of the aqueous azide ion with the O-H modes of bound water molecules, J. Phys. Chem. B 111, 14028-14033 (2007)
- Kim, YS; Hochstrasser, RM, The 2D IR responses of amide and carbonyl modes in water cannot be described by Gaussian frequency fluctuations, J. Phys. Chem. B 111, 9697-9701 (2007)
- Bagchi, S; Kim, YS; Charnley, AK; Smith, AB; Hochstrasser, RM, Two-dimensional infrared investigation of N-acetyl tryptophan methyl amide in solution, J. Phys. Chem. B 111, 3010-3018 (2007)
- Hochstrasser, RM, Two-dimensional spectroscopy at infrared and optical frequencies, Proc. Natl. Acad. Sci. U. S. A. 104, 14190-14196 (2007)
- Hochstrasser, RM, On a research rollercoaster with friends, Annu. Rev. Phys. Chem. 57, 37-64 (2006)
- Krause, CD; Mei, EW; Mirochnitchenko, O; Lavnikova, N; Xie, JX; Jia, YW; Hochstrasser, RM; Pestka, S, Interactions among the components of the interleukin-10 receptor complex, Biochem. Biophys. Res. Commun. 340, 377-385 (2006)
- Londergan, CH; Wang, JP; Axelsen, PH; Hochstrasser, RM, Two-dimensional infrared spectroscopy displays signatures of structural ordering in peptide aggregates, Biophys. J. 90, 4672-4685 (2006)
- Krause, CD; Lavnikova, N; Xie, JX; Mei, E; Mirochnitchenko, OV; Jia, YW; Hochstrasser, RM; Pestka, S, Preassembly and ligand-induced restructuring of the chains of the IFN-gamma receptor complex: the roles of Jak kinases, Stat1 and the receptor chains, Cell Res. 16, 55-69 (2006)
- Park, J; Hochstrasser, RM, Multidimensional infrared spectroscopy of a peptide intramolecular hydrogen bond, Chem. Phys. 323, 78-86 (2006)
- Kumar, K; Sinks, LE; Wang, JP; Kim, YS; Hochstrasser, RM, Coupling between C-D and C=O motions using dual-frequency 2D IR photon echo spectroscopy, Chem. Phys. Lett. 432, 122-127 (2006)
- Jiao, GS; Thoresen, LH; Kim, TG; Haaland, WC; Gao, F; Topp, MR; Hochstrasser, RM; Metzker, ML; Burgess, K, Syntheses, photophysical properties, and application of through-bond energy-transfer cassettes for biotechnology, Chem.-Eur. J. 12, 7816-7826 (2006)
- Gao, F; Mei, EW; Lim, M; Hochstrasser, RM, Probing lipid vesicles by bimolecular association and dissociation trajectories of single molecules, J. Am. Chem. Soc. 128, 4814-4822 (2006)
- Ha, JH; Kim, YS; Hochstrasser, RM, Vibrational dynamics of N-H, C-D, and C = O modes in formamide, J. Chem. Phys. 124, 64508 (2006)
- Kim, TG; Castro, JC; Loudet, A; Jiao, JGS; Hochstrasser, RM; Burgess, K; Topp, MR, Correlations of structure and rates of energy transfer for through-bond energy-transfer cassettes, J. Phys. Chem. A 110, 20-27 (2006)
- Mei, E; Hochstrasser, RM, High-resolution optical imaging from trajectory time distributions, J. Phys. Chem. B 110, 25101-25107 (2006)
- Kim, YS; Hochstrasser, RM, Comparison of linear and 2D IR spectra in the presence of fast exchange, J. Phys. Chem. B 110, 8531-8534 (2006)
- Wang, JP; Chen, JX; Hochstrasser, RM, Local structure of beta-hairpin isotopomers by FTIR, 2D IR, and ab initio theory, J. Phys. Chem. B 110, 7545-7555 (2006)
- Wang, JP; Hochstrasser, RM, Anharmonicity of amide modes, J. Phys. Chem. B 110, 3798-3807 (2006)
- Mei, E; Gao, F; Hochstrasser, RM, Controlled bimolecular collisions allow sub-diffraction limited microscopy of lipid vesicles, Phys. Chem. Chem. Phys. 8, 2077-2082 (2006)
- Sharonov, A; Hochstrasser, RM, Wide-field subdiffraction imaging by accumulated binding of diffusing probes, Proc. Natl. Acad. Sci. U. S. A. 103, 18911-18916 (2006)
- Fang, C; Senes, A; Cristian, L; DeGrado, WF; Hochstrasser, RM, Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer, Proc. Natl. Acad. Sci. U. S. A. 103, 16740-16745 (2006)
- Mei, E; Sharonov, A; Ferris, JH; Hochstrasser, RM, Direct visualization of nanopatterns by single-molecule imaging, Appl. Phys. Lett. 86,43102 (2005)
- Rubtsov, IV; Kumar, K; Hochstrasser, RM, Dual-frequency 2D IR photon echo of a hydrogen bond, Chem. Phys. Lett. 402, 439-443 (2005)
- Mei, EW; Gao, F; Vinogradov, S; Vanderkooi, JM; Hochstrasser, RM, Phosphorescence of individual horseradish peroxidases proteins having a modified heme group, Chem. Phys. Lett. 401, 30-34 (2005)
- Brinas, RP; Troxler, T; Hochstrasser, RM; Vinogradov, SA, Phosphorescent oxygen sensor with dendritic protection and two-photon absorbing antenna, J. Am. Chem. Soc. 127, 11851-11862 (2005)
- Fang, C; Hochstrasser, RM, Two-dimensional infrared spectra of the C-13=O-18 isotopomers of alanine residues in an alpha-helix, J. Phys. Chem. B 109, 18652-18663 (2005)
- Kim, YS; Wang, JP; Hochstrasser, RM, Two-dimensional infrared spectroscopy of the alanine dipeptide in aqueous solution, J. Phys. Chem. B 109, 7511-7521 (2005)
- Kim, YS; Hochstrasser, RM, Dynamics of amide-I modes of the alanine dipeptide in D2O, J. Phys. Chem. B 109, 6884-6891 (2005)
- Londergan, CH; Kim, YS; Hochstrasser, RM, Two-dimensional infrared spectroscopy of dipeptides in trehalose glass, Mol. Phys. 103, 1547-1553 (2005)
- Hochstrasser, RM, Techniques - Spectroscopy at a stretch, Nature 434, 570-571 (2005)
- Kim, YS; Hochstrasser, RM, Chemical exchange 2D IR of hydrogen-bond making and breaking, Proc. Natl. Acad. Sci. U. S. A. 102, 11185-11190 (2005)
- Rubtsov, IV; Kim, YS; Hochstrasser, RM, Dynamical models in the two-dimensional infrared spectroscopy of peptides, Isr. J. Chem. 44, 271-280 (2004)
- E. Mei, A. Sharonov, F. Gao, J. H. Ferris, and R. M. Hochstrasser, “Anamalously slow diffusion of single molecules near a patterned surface” J. Phys. Chem. A. 108 (36), 7339-7346 (2004)
- I. V. Rubtsov, Y. S. Kim, R. M. Hochstrasser, “Dynamical models in the two- dimensional infrared spectroscopy of peptides”, Isr. J. Chem. 44 (1-3), 271-280 (2004)
- J. Park, J. –H. Ha, and R. M. Hochstrasser, “Multidimensional infrared spectroscopy of the N-H bond motions in formamide”, J. Chem. Phys. 121 (15), 7281-7292 (2004)
- J. Tang, E. Mei, C. Green, J. Kaplan, W. F. DeGrado, A. B. Smith III, and R. M. Hochstrasser, “Probing structural dynamics of individual calmodulin: peptide complexes in hydrogel by single molecule confocal microscopy” J. Phys. Chem. B 108, 15910-15918 (2004)
- S. Gnanakaran, R. M. Hochstrasser, and A. E. García, “Nature of structural inhomogeneities on folding a helix and their influence on spectral measurements” Proc. Natl. Acad. Sci. U.S.A. 101 (25), 9229-9234 (2004)
- C. Fang, J. Wang, Y. S. Kim, A. K. Charnley, W. Barber-Armstrong, A. B. Smith III, S. M. Decatur, and R. M. Hochstrasser, “Two-dimensional infrared spectroscopy of isotopomers of an alanine rich alpha-helix”, J. Phys. Chem. B 108, 10415-10427 (2004)
- I. V. Rubtsov, N. P. Redmore, R. M. Hochstrasser, and M. J. Therien, “Interrogating conformationally dependent electron-transfer dynamics via ultrafast visible pump/IR probe spectroscopy”, J. Am. Chem. Soc. 126, 2684-2685 (2004).
- J. Wang & R.M. Hochstrasser “Characteristics of the two-dimensional infrared spectroscopy of helices from approximate simulations and analytic models. Chem. Phys. 297, 195-219 (2004).
- C. Paul, J. Wang, W.C. Wimley, R.M. Hochstrasser, P.H. Axelsen “Vibrational Coupling, Isotopic Edition, and beta-sheet structure in a membrane-bound polypeptide”, J. Am. Chem. Soc. 126, 5843-5850 (2004).
- C. Fang, J. Wang, A. K. Charnley, W. Barber-Armstrong, A. B. Smith III, S. M. Decatur, R.M. Hochstrasser “Two dimensional IR measurements of the coupling between amide modes of an a-helix”, Chem. Phys. Lett. 382, 586-592 (2003).
- J. Chen, J. Park, and R. M. Hochstrasser “Nonlinear Infrared Responses of the N-H Mode of Pyrrole in Carbon Tetrachloride by Heterodyned and Stimulated Echoes”, J. Phys. Chem. A. 107 (49), 10660-10666 (2003).
- E. Mei, S. Vinogradov, and R. M. Hochstrasser “Direct observation of triplet emission of single molecules: single molecule phosphorescence quenching of metalloporphyrin and organometallic complexes by molecular oxygen and quenching rate distributions”, J. Am. Chem. Soc. 125 (43), 13198-13204 (2003).
- I. V. Rubtsov, J. Wang, and R. M. Hochstrasser “Dual-frequency 2D-IR spectroscopy heterodyned photon echo of the peptide bond”, Proc. Natl. Acad. Sci. U.S.A. 100 (10), 5601-5606 (2003).
- I. V. Rubtsov, J. Wang, and R. M. Hochstrasser “Vibrational Coupling between Amide-I and Amide-A Modes Revealed by Femtosecond Two Color Infrared Spectroscopy”, J. Phys. Chem. A. 107 (18), 3384-3396 (2003).
- I. V. Rubtsov, J. Wang, and R. M. Hochstrasser “Dual Frequency 2D-IR of Amide-A and Amide-I Modes”, J. Chem. Phys. 118 (17), 7733-7736 (2003).
- E. Mei, J. Tang, J. M. Vanderkooi, and R.M. Hochstrasser “Motions of Single Molecules and Proteins in Trehalose Glass”, J. Am. Chem. Soc. 125, 2730-2735 (2003).













