The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Assembly index calculation shown to be NP-complete

A new paper involving the Cronin group analyses assembly theory in the context of computational complexity, clarifying how the assembly index differs formally from common information and compression measures. The work presents counterexamples showing that assembly index is not equivalent to Huffman coding, Shannon entropy, or Lempel Ziv style compression, and demonstrates that computing the assembly index for a class of string assembly problems is NP-complete. The paper also discusses why these computational properties do not undermine the intended role of assembly index as a physically grounded, measurable quantity for characterising evolved complexity and supporting life detection metrology.

Full article available here

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Advanced Research Centre (ARC)
Level 5, Digital Chemistry
University of Glasgow
11 Chapel Lane
Glasgow G11 6EW
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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529. Chemputer and chemputation—A universal chemical compound synthesis machine

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528. Verification and execution of the scientific literature via chemputation augmented by large language models

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527. Chemical programming of kinase inhibitors in a modular chemputer-based system

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526. Organophosphonate Ligation Approach for the Controlled Assembly of Gigantic Polyoxometalate Clusters

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525. Spontaneous assemblies of gigantic polyoxomolybdates; from structure and properties to synthetic methods

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524. ElectroChemputer with integrated monitoring for programmable electrochemistry

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523. Achieving Operational Universality through a Turing Complete Chemputer

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522. AI-driven robotic crystal explorer for rapid polymorph identification

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521. Rapid Exploration of the Assembly Chemical Space of Molecular Graphs

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520. Programmable Microwaveable Chemistry in the Chemputer


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