The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Assembly index calculation shown to be NP-complete

A new paper involving the Cronin group analyses assembly theory in the context of computational complexity, clarifying how the assembly index differs formally from common information and compression measures. The work presents counterexamples showing that assembly index is not equivalent to Huffman coding, Shannon entropy, or Lempel Ziv style compression, and demonstrates that computing the assembly index for a class of string assembly problems is NP-complete. The paper also discusses why these computational properties do not undermine the intended role of assembly index as a physically grounded, measurable quantity for characterising evolved complexity and supporting life detection metrology.

Full article available here

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Advanced Research Centre (ARC)
Level 5, Digital Chemistry
University of Glasgow
11 Chapel Lane
Glasgow G11 6EW
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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516. Universal peptide synthesis via solid-phase methods fused with chemputation

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515. Regulating the Assembly of γ-Cyclodextrin Host and Polyoxometalate-Based Guests toward Light-Responsive Hybrid Rotaxanes

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514. Natural-Language-Interfaced Robotic Synthesis for AI-Copilot-Assisted Exploration of Inorganic Materials

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513. Robotic exploration of amino-acid functionalised molybdenum blue polyoxometalate nanoclusters

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512. A programmable modular robot for the synthesis of molecular machines

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511. Compression of Molybdenum Blue Polyoxometalate Cluster Rings

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510. High-Nuclearity Polyoxometalate-Based Metal–Organic Frameworks for Photocatalytic Oxidative Cleavage of C−C Bond

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509. Breaking the Boundary of Gigantic Molybdenum Blue Clusters: From Half-Closed {Mo85} to {Mo172} Dimer

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508. Operational considerations for approximating molecular assembly by Fourier transform mass spectrometry

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507. Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer


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