Autonomous Synthesis Streamlines Construction of Molecular Machines
Researchers from the Cronin Group have developed an autonomous platform for the synthesis of molecular machines using the Chemputer. In a recent Chem publication, the team reports the programmable assembly of a series of [2]rotaxanes by integrating real-time NMR and liquid chromatography feedback within the XDL chemical programming language.
This was achieved by dynamically adjusting process conditions during synthesis, ensuring controlled reaction progression and purification with minimal human intervention. These advances automate traditionally time- and labour-intensive procedures, providing a scalable and reproducible approach to constructing advanced molecular architectures. By freeing researchers from repetitive experimental work, the Chemputer opens new opportunities for exploratory research and the broader automation of complex molecule synthesis.