The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Autonomous Synthesis Streamlines Construction of Molecular Machines

Researchers from the Cronin Group have developed an autonomous platform for the synthesis of molecular machines using the Chemputer. In a recent Chem publication, the team reports the programmable assembly of a series of [2]rotaxanes by integrating real-time NMR and liquid chromatography feedback within the XDL chemical programming language.

This was achieved by dynamically adjusting process conditions during synthesis, ensuring controlled reaction progression and purification with minimal human intervention. These advances automate traditionally time- and labour-intensive procedures, providing a scalable and reproducible approach to constructing advanced molecular architectures. By freeing researchers from repetitive experimental work, the Chemputer opens new opportunities for exploratory research and the broader automation of complex molecule synthesis.

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Advanced Research Centre (ARC)
Level 5, Digital Chemistry
University of Glasgow
11 Chapel Lane
Glasgow G11 6EW
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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509. High-Nuclearity Polyoxometalate-Based Metal–Organic Frameworks for Photocatalytic Oxidative Cleavage of C−C Bond

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508. Operational considerations for approximating molecular assembly by Fourier transform mass spectrometry

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507. Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer

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506. Experimentally measured assemblyindices are required to determine the threshold for life

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505. Algorithm-driven robotic discovery of polyoxometalate-scaffolding metal–organic frameworks

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504. Reaction: Programmable chemputable click chemistry

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503. Rethinking pharma and biotech outsourcing: A call for data security and supply chain resilience

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502. Delocalized, asynchronous, closed-loop discovery of organic laser emitters

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501. Investigating and Quantifying Molecular Complexity Using Assembly Theory and Spectroscopy

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500. Electron density-based GPT for optimization and suggestion of host–guest binders


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