The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Chemputer Trial at NIH-NCATS Advances Collaborative Automation Efforts

As part of the ongoing collaboration between the Cronin Group and the National Institutes of Health’s National Center for Advancing Translational Sciences (NIH-NCATS), PhD students Nathan Jiscoot and Dominika Urbanczyk visited the NCATS facility in Rockville, Maryland to support the installation and testing of a ChemPU platform. The visits focused on adapting a manually executed four-step synthetic route—previously unscaled—to an automated workflow using the ChemPU system.The synthesis targeted an analogue of a drug building block reported to reduce inflammation and mitigate traumatic brain injury pathology with improved selectivity [Mason et al.Redox Biol. 2023, 60, 102611]. The visit demonstrated the strength of the XDL programming language in capturing complex workflows, highlighting its potential to support integrated chemical automation.

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Advanced Research Centre (ARC)
Level 5, Digital Chemistry
University of Glasgow
11 Chapel Lane
Glasgow G11 6EW
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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509. High-Nuclearity Polyoxometalate-Based Metal–Organic Frameworks for Photocatalytic Oxidative Cleavage of C−C Bond

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508. Operational considerations for approximating molecular assembly by Fourier transform mass spectrometry

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507. Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer

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506. Experimentally measured assemblyindices are required to determine the threshold for life

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505. Algorithm-driven robotic discovery of polyoxometalate-scaffolding metal–organic frameworks

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504. Reaction: Programmable chemputable click chemistry

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503. Rethinking pharma and biotech outsourcing: A call for data security and supply chain resilience

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502. Delocalized, asynchronous, closed-loop discovery of organic laser emitters

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501. Investigating and Quantifying Molecular Complexity Using Assembly Theory and Spectroscopy

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500. Electron density-based GPT for optimization and suggestion of host–guest binders


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