Digital Chemistry breakthrough with two landmark papers on Chemputer-based Optimisation and Inert atmosphere manipulations
The Schlenkputer, published in Nature Chemical Engineering , is a fully automated system for conducting highly reactive chemical reactions in an inert atmosphere. The system combines a programmable Schlenk line for inertization of glassware with a liquid handling backbone, allowing for the synthesis and manipulation of air and moisture-sensitive compounds. The researchers demonstrated the system’s capabilities by synthesizing four highly reactive compounds, including a colorimetric indicator and a hygroscopic Lewis acid. The Schlenkputer provides a safe and efficient platform for conducting sensitive chemical reactions, potentially revolutionizing the field of chemical synthesis.
Also introduced this month in Nature Communications is a new system for automated chemical synthesis that can adapt to changing circumstances in real-time. The system utilizes low-cost sensors and analytical instruments to monitor and optimize chemical reactions, resulting in improved yields and reduced human intervention. The researchers demonstrated the system’s capabilities by optimizing reactions such as the Ugi four-component reaction and the Van Leusen oxazole synthesis.
Both papers are published as Open Access.