Effect of Heterogeneity

Does heterogeneity reduce the resolution to which crystals diffract?

The resolution limit is determined by the crystal contacts.

Same crystal contacts - Same resolution?

To improve resolution you must find a new crystal form where the molecules are packed together more tightly or have more extensive crystal contacts

Crystals can accomodate heterogeneity such as carbohydrate chains in glycosylated proteins.
Why would crystals of glycosylated proteins diffract poorly?