EPO and EPO receptor:

Press Release

Crystal Structure:

Oded Livnah, Enrico A. Stura, Dana L. Johnson, Linda S.Mulcahy, Nicholas C. Wrighton, William J. Dower, Linda K. Jolliffe, and Ian A. Wilson (1996) Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8Å. Science 273:464-471.

Perspectives by James A. Wells

Cell parameters Resolution (Å)
P212121, a = 58.8 Å, b = 75.0 Å, c = 130.5 Å 2.3
The receptor was crystallized in complex with a cyclic peptide. A full crystallization paper is in preparation.

This is a project in collaboration with R. W. Johnson: Linda Jolliffe and Dana Johnson. Oded Livnah has been responsible for the structure determination. Two heavy atom derivatives: Mercury acetate and Uranyl Nitrate were used for phasing of the data.

Signal transduction

This project was carried out in the Ian Wilson Laboratory.