The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Cronin Group Builds Chemputer to Chemify Chemical Space

Cronin group researchers have built a “Chemputer” chemical computer system, coupled with a chemical programming language, allowing researchers to reliably and automatically synthesise organic molecules. In the research, published in Science, this approach was used to synthesise three pharmaceutical compounds – Nytol, rufinamide, and sildenafil – without any human interaction, and with yields comparable to or better than those achieved manually. The digital code for these processes can be published, versioned, and transferred flexibly between platforms with no modification, thereby greatly enhancing reproducibility and reliable access to complex molecules.

This research represents a leap forward in the ultimate aim to develop a commercial, universal chemical computer, that could revolutionise chemistry.It has been covered by multiple news sites including Chemistry World and C&EN. Further information and code can be found on the project homepage and on the Chemputer twitter feed.

Click the news item image to see the Chemputer process in action.

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Cronin Laboratory
School of Chemistry
Joseph Black Building
University of Glasgow
Glasgow G12 8QQ
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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452. [Fe15]: a frustrated, centred tetrakis hexahedron

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451. Robotic Stepwise Synthesis of Hetero-Multinuclear Metal Oxo Clusters as Single-Molecule Magnets

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450. Standardization and Control of Grignard Reactions in a Universal Chemical Synthesis Machine using online NMR

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449. A robotic prebiotic chemist probes long term reactions of complexifying mixtures

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448. Identifying molecules as biosignatures with assembly theory and mass spectrometry

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447. A molecular computing approach to solving optimization problems via programmable microdroplet arrays

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446. Influence of the Contact Geometry and Counterions on the Current Flow and Charge Transfer in Polyoxometalate Molecular Junctions: A Density Functional Theory Study

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445. Elucidating the Paramagnetic Interactions of an Inorganic-Organic Hybrid Radical-Functionalized Mn-Anderson Cluster

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444. Automatic Generation of 3D-Printed Reactionware for Chemical Synthesis Digitization using ChemSCAD

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443. Optimization of Formulations Using Robotic Experiments Driven by Machine Learning DoE


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