The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Joint US-UK Solution wins NIH Integrated Challenge Prize

The teams of Prof Walker from Arizona State University and Prof Cronin from Glasgow University have won a challenge prize for innovative solutions working towards innovation in pain, opioid use disorder and overdose.

The joint team combines expertise in exploring chemical space using statistical methods (ASU) with a programmable chemical robot for molecular discovery and synthesis (GU). Their project proposes a solution called ‘Integrated Discovery Chemputer Toward Addiction Free Opiates (ChemOPs)’.

The challenge solution proposes an integrated solution that leverages the Glasgow-based programmable chemical robot, ‘the Chemputer’ for the design and discovery of new candidate molecules for drug discovery, using network approaches to exploring chemical space devised by the ASU team. The integrated system will link a chemical database with the generation of chemical code that will operate the Chemputer to then make the drug candidates.

The prize announcement can be found at https://ncats.nih.gov/aspire/2018ChallengeWinners#c5

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Cronin Laboratory
School of Chemistry
Joseph Black Building
University of Glasgow
Glasgow G12 8QQ
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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452. [Fe15]: a frustrated, centred tetrakis hexahedron

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451. Robotic Stepwise Synthesis of Hetero-Multinuclear Metal Oxo Clusters as Single-Molecule Magnets

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450. Standardization and Control of Grignard Reactions in a Universal Chemical Synthesis Machine using online NMR

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449. A robotic prebiotic chemist probes long term reactions of complexifying mixtures

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448. Identifying molecules as biosignatures with assembly theory and mass spectrometry

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447. A molecular computing approach to solving optimization problems via programmable microdroplet arrays

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446. Influence of the Contact Geometry and Counterions on the Current Flow and Charge Transfer in Polyoxometalate Molecular Junctions: A Density Functional Theory Study

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445. Elucidating the Paramagnetic Interactions of an Inorganic-Organic Hybrid Radical-Functionalized Mn-Anderson Cluster

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444. Automatic Generation of 3D-Printed Reactionware for Chemical Synthesis Digitization using ChemSCAD

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443. Optimization of Formulations Using Robotic Experiments Driven by Machine Learning DoE


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