Publications

74
Total Synthesis of 7-epi-Pukalide and 7-Acetylsinumaximol B
K. McAulay, J. S. Clark, Chem. Eur. J. 2017, 23, 9761-9765.
Link: 10.1002/chem.201702591
chemeurj2017


73
Trialkylphosphine-Mediated Synthesis of 2-Acyl Furans from Ynenones
C. Xu, S. Wittmann, M. Gemander, V. Ruohonen, J. S. Clark, Org. Lett. 2017, 28, 3556-3559.
Link: 10.1021/acs.orglett.7b01533
orglett2017


72
Tioether–Catalysed Tandem Synthesis of Furans and Cyclic Ethers or Lactones
V. Klaus, J. S. Clark Synlett 2017, 28, 1358-1362.
Link: 10.1055/s-0036-1588758
Synlett2017


71
Total Synthesis of (−)-Nakadomarin A
J. S. Clark, C. Xu, Angew. Chem. Int. Ed. 2016, 13, 4332-4335.
Link: 10.1002/anie.201600990
AngewChem2016


70
Synthesis of the A‐D Ring System of the Gambieric Acids
J. S. Clark, F. Romiti, B. Sieng, L. C. Paterson, A. Stewart, S. Chaudhury and L. H. Thomas, Org. Lett. 2015, 17, 4694-4697.
Link: 10.1021/acs.orglett.5b02093
orglett2015


69
Synthesis of Cyclopropyl-Substituted Furans by Brønsted Acid Promoted Cascade Reactions
J. S. Clark, F. Romiti, K. F. Hogg, M. H. S. A. Hamid, S. C. Richter, A. Boyer, J. C. Redman and L. J. Farrugia, Angew. Chem. Int. Ed. 2015, 54, 5744-5747.
Link: 10.1002/anie.201500625
Angewcheminted2015


68
Synthesis of Four Diastereomers of Sclerophytin F and Structural Reassignment of Several Sclerophytin Natural Products
J. S. Clark, L. Delion, L. J. Farrugia, Chem. Eur. J. 2015, 21, 4772-4780.
Link: 10.1002/chem.201406051
chemeurj2015


67
Total Synthesis of the Purported Structure of Sclerophytin F
J. S. Clark, L. Delion, L. J. Farrugia, Org. Lett. 2014, 16, 4300-4303.
Link: 10.1021/ol5020152
orglett2014


66
Intramolecular Reactions of Metal Carbenoids with Allylic Ethers: Is a Free Ylide Involved in Every Case?
J. S. Clark, K. E. Hansen, Chem. Eur. J. 2014, 20, 5454-5459.
Link: 10.1002/chem.201304054
chemeurj2014


65
Total Syntheses of Amphidinolides T1, T3, and T4
J. S. Clark, F. Romiti, Angew. Chem. Int. Ed. 2013, 52, 10072-10075.
Link: 10.1002/anie.201305467
angewchem2013


64
Synthesis of the C-1–C-17 Fragment of Amphidinolides C, C2, C3, and F
J. S. Clark, G. Yang, A. P. Osnowski, Org. Lett. 2013, 15, 1460-1463.
Link: 10.1021/ol4004838
orglett2013-2


63
Synthesis of the C-18–C-34 Fragment of Amphidinolides C, C2, and C3
J. S. Clark, G. Yang, A. P. Osnowski, Org. Lett. 2013, 15, 1464-1467.
Link: 10.1021/ol400482j
orglett2013-1


62
Total Syntheses of Multiple Cladiellin Natural Products by Use of a Completely General Strategy
J. S. Clark, R. Berger, S. T. Hayes, H. M. Senn, L. J. Farrugia, L. H. Thomas, A. J. Morrison, L. Gobbi, J. Org. Chem. 2013, 78, 673-696.
Link: 10.1021/jo302542h
orgchem2013


61
Organocatalytic Synthesis of Highly Substituted Furfuryl Alcohols and Amines
J. S. Clark, A. Boyer, A. Aimon, P. Engel García, D. M. Lindsay, A. D. F. Symington, Y. Danoy, Angew. Chem. Int. Ed. 2012, 51, 12128-12131.
Link: 10.1002/anie.201207300
angew2012


60
Synthesis of the Tricyclic Core of Labiatin A and Australin A
J. S. Clark, D. Vignard, A. Parkin, Org. Lett. 2011, 13, 3980-3983.
Link: 10.1021/ol201498gorglett2011

59
Concise synthesis of the C-1–C-12 fragment of amphidinolides T1-T5
J. S. Clark, F. Labre, L. H. Thomas, Organic & Biomolecular Chemistry 2011, 9, 4823-4830.
Link: 10.1039/C1OB05130Jorgbiomolchem2009

58
Enantioselective Total Syntheses of Three Cladiellins (Eunicellins): A General Approach to the Entire Family of Natural Products
J. S. Clark, R. Berger, S. T. Hayes, L. H. Thomas, A. J. Morrison, L. Gobbi, Angew. Chem. Int. Ed. 2010, 49, 9867-9870.
Link: 10.1002/anie.201005508
57
Synthetic studies on the cornexistins: synthesis of (±)-5-epi-hydroxycornexistin
J. S. Clark, J. M. Northall, F. Marlin, B. Nay, C. Wilson, A. J. Blake, M. J. Waring, Organic & Biomolecular Chemistry 2008, 6, 4012-4025.
Link: 10.1039/B811245B

56
Stereoselective Construction of the Tricyclic Core of Neoliacinic Acid
J. S. Clark, C. A. Baxter, A. G. Dossetter, S. Poigny, J. L. Castro, W. G. Whittingham, J. Org. Chem. 2008, 73, 1040-1055.
Link: 10.1021/jo702111u

55
A Concise Total Synthesis of (±)-Vigulariol
J. S. Clark, S. T. Hayes, C. Wilson, L. Gobbi, Angew. Chem. Int. Ed. 2007, 46, 437-440.
Link: 10.1002/anie.200603880

54
Synthesis of a lactone natural product found in Greek tobacco
J. S. Clark, S. T. Hayes, A. J. Blake, L. Gobbi, Tetrahedron Lett. 2007, 48, 2501-2503.
Link: 10.1016/j.tetlet.2007.02.039

53
Rapid synthesis of medium-ring fused polycarbocyclic systems by rearrangement of carbenoid-derived oxonium ylides
J. S. Clark, C. Guerot, C. Wilson, A. J. Blake, Chem. Commun. 2007, 4134-4136.
Link: 10.1039/B709064A

52
Synthesis of the Fused Polyether Core of Hemibrevetoxin B by Two-Directional Ring-Closing Metathesis
J. S. Clark, D. M. Grainger, A. A. C. Ehkirch, A. J. Blake, C. Wilson, Org. Lett. 2007, 9, 1033-1036.
Link: 10.1021/ol0630651

51
Rapid Synthesis of the A–E Fragment of Ciguatoxin CTX3C
J. S. Clark, J. Conroy, A. J. Blake, Org. Lett. 2007, 9, 2091-2094.
Link: 10.1021/ol0706096

50
Synthetic Studies on the Cladiellins (Eunicellins): Unexpected Selenoxide–Displacement with Concomitant Alcohol Oxidation During Attempted–Selenoxide Elimination
J. S. Clark, L. J. Winfield, C. Wilson, A. J. Blake, Synlett 2006, 2006, 2191-2194.
Link: 10.1055/s-2006-949611

49
Construction of Fused Medium-Ring Carbocycles by Catalytic Generation and Rearrangement of Oxonium Ylides
J. S. Clark, S. B. Walls, C. Wilson, S. P. East, M. J. Drysdale, Eur. J. Org. Chem. 2006, 2006, 323-327.
Link: 10.1002/ejoc.200500830

48
A concise enantioselective synthesis of the fungal metabolite (+)-decarestrictine L
J. S. Clark, T. C. Fessard, G. A. Whitlock, Tetrahedron 2006, 62, 73-78.
Link: 10.1016/j.tet.2005.09.144

47
Construction of fused polycyclic ethers by strategies involving ring-closing metathesis
J. S. Clark, Chem. Commun. 2006, 3571-3581.
Link: 10.1039/B601839D

46
Tuneable asymmetric copper-catalysed allylic amination and oxidation reactions
J. S. Clark, C. Roche, Chem. Commun. 2005, 5175-5177.
Link: 10.1039/B509678B

45
Investigation of the Biomimetic Synthesis of Emindole SB Using a Fluorinated Polyene Cyclisation Precursor
J. S. Clark, J. Myatt, L. Roberts, N. Walshe, Synlett 2005, 2005, 697-699.
Link: 10.1055/s-2005-863721

44
Rapid Two-Directional Synthesis of the F–J Fragment of the Gambieric Acids by Iterative Double Ring-Closing Metathesis
J. S. Clark, M. C. Kimber, J. Robertson, C. S. P. McErlean, C. Wilson, Angew. Chem. Int. Ed. 2005, 44, 6157-6162.
Link: 10.1002/anie.200501925

43
Synthesis of the Tricyclic Core of the Marine Natural Product Labiatin A
J. S. Clark, C. A. Baxter, J. L. Castro, Synthesis 2005, 2005, 3398-3404.
Link: 10.1055/s-2005-918485

42
Stereoselective synthesis of the cyclic ether core of (+)-laurenyne
J. S. Clark, R. P. Freeman, M. Cacho, A. W. Thomas, S. Swallow, C. Wilson, Tetrahedron Lett. 2004, 45, 8639-8642.
Link: 10.1016/j.tetlet.2004.09.160

41
A Concise and Stereoselective Synthesis of the A-Ring Fragment of the Gambieric Acids
J. S. Clark, T. C. Fessard, C. Wilson, Org. Lett. 2004, 6, 1773-1776.
Link: 10.1021/ol049483s

40
Construction of building-blocks for polyether synthesis using sequential catalytic ring-closing enyne and cross metathesis
J. S. Clark, F. Elustondo, M. C. Kimber, Chem. Commun. 2004, 2470-2471.
Link: 10.1039/B409067E

39
Anomalous Intramolecular C-H Insertion Reactions of Rhodium Carbenoids: Factors Influencing the Reaction Course and Mechanistic Implications
J. S. Clark, A. G. Dossetter, Y.-S. Wong, R. J. Townsend, W. G. Whittingham, C. A. Russell, J. Org. Chem. 2004, 69, 3886-3898.
Link: 10.1021/jo049900e

38
Asymmetric allylic oxidation of bridged-bicyclic alkenes using a copper-catalysed symmetrising-desymmetrising Kharasch–Sosnovsky reaction
J. S. Clark, M.-R. Clarke, J. Clough, A. J. Blake, C. Wilson, Tetrahedron Lett. 2004, 45, 9447-9450.
Link: 10.1016/j.tetlet.2004.10.093

37
Stereoselective synthesis of tetrahydropyran-3-ones by rearrangement of oxonium ylides generated from metal carbenoids
J. Stephen Clark, G. Whitlock, S. Jiang, N. Onyia, Chem. Commun. 2003, 2578-2579.
Link: 10.1039/B307858M

36
Exploration of the biomimetic synthesis of indole-diterpene mycotoxins: an unexpected cascade reaction during the attempted synthesis of emindole SB
J. Stephen Clark, J. Myatt, C. Wilson, L. Roberts, N. Walshe, Chem. Commun. 2003, 1546-1547.
Link: 10.1039/B302105J

35
Direct peptide coupling of novel amino acid derivatives produced by rearrangement of catalytically generated ammonium ylides
J. S. Clark, M. D. Middleton, Tetrahedron Lett. 2003, 44, 7031-7034.
Link: 10.1016/S0040-4039(03)01778-7

34
Preparation of cyclic ethers for polyether synthesis by catalytic ring-closing enyne metathesis of alkynyl ethers
J. Stephen Clark, F. Elustondo, G. P. Trevitt, D. Boyall, J. Robertson, A. J. Blake, C. Wilson, B. Stammen, Tetrahedron 2002, 58, 1973-1982.
Link: 10.1016/S0040-4020(02)00053-4

33
Synthesis of Novel α-Substituted and α,α-Disubstituted Amino Acids by Rearrangement of Ammonium Ylides Generated from Metal Carbenoids
J. S. Clark, M. D. Middleton, Org. Lett. 2002, 4, 765-768.
Link: 10.1021/ol017240j

32
Synthesis of the Carbocyclic Core of the Cornexistins by Ring-Closing Metathesis
J. S. Clark, F. Marlin, B. Nay, C. Wilson, Org. Lett. 2002, 5, 89-92.
Link: 10.1021/ol027265y

31
Diels-Alder adducts of medium-ring carbocyclic dienes prepared by rearrangement of catalytically generated cyclic oxonium ylides
C. Wilson, J. S. Clark, A. L. Bate, A. J. Blake, T. Grinter, S. J. Teat, Acta Crystallographica Section C 2001, 57, 1326-1329.
Link: 10.1107/S0108270101013440

30
Probing the mechanism of the anomalous intramolecular C–H insertion reaction of rhodium carbenoids by analysis of kinetic isotope effects
J. S. Clark, Y.-S. Wong, R. J. Townsend, Tetrahedron Lett. 2001, 42, 6187-6190.
Link: 10.1016/S0040-4039(01)01173-X

29
A concise enantioselective synthesis of the AB ring system of the manzamine alkaloids by ring-closing enyne metathesis
J. S. Clark, R. J. Townsend, A. J. Blake, S. J. Teat, A. Johns, Tetrahedron Lett. 2001, 42, 3235-3238.
Link: 10.1016/S0040-4039(01)00404-X

28
Rearrangement of ammonium ylides produced by intramolecular reaction of catalytically generated metal carbenoids. Part 1. Synthesis of cyclic amines
J. S. Clark, P. B. Hodgson, M. D. Goldsmith, L. J. Street, J. Chem. Soc., Perkin Trans. 1 2001, 3312-3324.
Link: 10.1039/B108179A

27
Rearrangement of ammonium ylides produced by intramolecular reaction of catalytically generated metal carbenoids. Part 2. Stereoselective synthesis of bicyclic amines
J. S. Clark, P. B. Hodgson, M. D. Goldsmith, A. J. Blake, P. A. Cooke, L. J. Street, J. Chem. Soc., Perkin Trans. 1 2001, 3325-3337.
Link: 10.1039/B108182A

26
A novel approach to the construction of medium-ring carbocycles utilising the rearrangement of oxonium ylides generated from metal carbenoids
J. S. Clark, A. L. Bate, T. Grinter, Chem. Commun. 2001, 459-460.
Link: 10.1039/B100292I

25
Construction of the 11-oxabicyclo[6.2.1]undecane core of the cladiellins by a novel rearrangement reaction
J. S. Clark, Y.-S. Wong, Chem. Commun. 2000, 1079-1080.
Link: 10.1039/B002511I

24
Synthesis of Polycyclic Ethers by Two-Directional Double Ring-Closing Metathesis
J. S. Clark, O. Hamelin, Angew. Chem. 2000, 112, 380-382.
Link: 10.1002/(SICI)1521-3757(20000117)112:2<380::AID-ANGE380>3.0.CO;2-R

23
Synthesis of the functionalised core of neoliacinic acid
J. Stephen Clark, A. G. Dossetter, A. J. Blake, W.-S. Li, W. G. Whittingham, Chem. Commun. 1999, 749-750.
Link: 10.1039/A901711I

22
Synthesis of Sub-units of Marine Polycyclic Ethers by Ring-closing Metathesis and Hydroboration of Enol Ethers
J. S. Clark, J. G. Kettle, Tetrahedron 1999, 55, 8231-8248.
Link: 10.1016/S0040-4020(99)00303-8

21
Enantioselective propargylic oxidation
J. Stephen Clark, K. F. Tolhurst, M. Taylor, S. Swallow, Tetrahedron Lett. 1998, 39, 4913-4916.
Link: 10.1016/S0040-4039(98)00894-6

20
Synthesis of alkenyl-substituted cyclic enol ethers by catalytic ring-closing metathesis of alkynyl ethers
J. Stephen Clark, G. P. Trevitt, D. Boyall, B. Stammen, Chem. Commun. 1998, 2629-2630.
Link: 10.1039/A807667G

19
Enantioselective allylic acyloxylation catalysed by copper-oxazoline [dagger] complexes
J. Stephen Clark, K. F. Tolhurst, M. Taylor, S. Swallow, J. Chem. Soc., Perkin Trans. 1 1998, 1167-1170.
Link: 10.1039/A801238E

18
Synthesis of medium-sized cyclic allylic ethers by ring-closing metathesis and subsequent elaboration to sub-units found in the brevetoxins and ciguatoxins
J. S. Clark, O. Hamelin, R. Hufton, Tetrahedron Lett. 1998, 39, 8321-8324.
Link: 10.1016/S0040-4039(98)01825-5

17
Asymmetric Synthesis of Cyclic Ethers by Rearrangement of Oxonium Ylides Generated from Chiral Copper Carbenoids
J. S. Clark, M. Fretwell, G. A. Whitlock, C. J. Burns, D. N. A. Fox, Tetrahedron Lett. 1998, 39, 97-100.
Link: 10.1016/S0040-4039(97)10441-5

16
Enantioselective synthesis of medium-ring sub-units of brevetoxin A by ring-closing metathesis
J. Stephen Clark, J. G. Kettle, Tetrahedron Lett. 1997, 38, 127-130.
Link: 10.1016/S0040-4039(96)02233-2

15
Synthesis of brevetoxin sub-units by sequential ring-closing metathesis and hydroboration
J. S. Clark, J. G. Kettle, Tetrahedron Lett. 1997, 38, 123-126.
Link: 10.1016/S0040-4039(96)02232-0

14
Anomalous Products from Intramolecular Insertion Reactions of Rhodium Carbenoids into the α-C–H Bonds of Ethers
J. S. Clark, A. G. Dossetter, C. A. Russell, W. G. Whittingham, J. Org. Chem. 1997, 62, 4910-4911.
Link: 10.1021/jo970842p

13
Synthesis of Medium Ring Ethers. 5. The Synthesis of (+)-Laurencin
J. W. Burton, J. S. Clark, S. Derrer, T. C. Stork, J. G. Bendall, A. B. Holmes, J. Am. Chem. Soc. 1997, 119, 7483-7498.
Link: 10.1021/ja9709132

12
Stereoselective synthesis of the bicyclic core structure of the highly oxidised sesquiterpene neoliacinic acid
J. S. Clark, A. G. Dossetter, W. G. Whittingham, Tetrahedron Lett. 1996, 37, 5605-5608.
Link: 10.1016/0040-4039(96)01136-7

11
An enantioselective synthesis of the CE ring system of the alkaloids manzamine A, E and F, and ircinal a
J. Stephen Clark, P. B. Hodgson, Tetrahedron Lett. 1995, 36, 2519-2522.
Link: 10.1016/0040-4039(95)00296-O

10
A short synthesis of (±)-decarestrictine L
J. S. Clark, G. A. Whitlock, Tetrahedron Lett. 1994, 35, 6381-6382.
Link: 10.1016/S0040-4039(00)73438-1

9
Intramolecular generation and rearrangement of ammonium ylides from copper carbenoids: a general method for the synthesis of cyclic amines
J. S. Clark, P. B. Hodgson, J. Chem. Soc., Chem. Commun. 1994, 2701-2702.
Link: 10.1039/C39940002701

8
Synthesis of cyclic ethers from copper carbenoids by formation and rearrangement of oxonium ylides
J. S. Clark, S. A. Krowiak, L. J. Street, Tetrahedron Lett. 1993, 34, 4385-4388.
Link: 10.1016/S0040-4039(00)79359-2

7
Diastereoselective Anti Aldol Reactions of Chiral Ethyl Ketones. Enantioselective Processes for the Synthesis of Polypropionate Natural Products
D. A. Evans, H. P. Ng, J. S. Clark, D. L. Rieger, Tetrahedron 1992, 48, 2127-2142.
Link: 10.1016/S0040-4020(01)88879-7

6
Diastereoselective synthesis of 2,5-dialkyl tetrahydrofuran-3-ones by a copper-catalysed tandem carbenoid insertion and ylide rearrangement reaction
J. S. Clark, Tetrahedron Lett. 1992, 33, 6193-6196.
Link: 10.1016/S0040-4039(00)60041-2

5
Synthesis of medium ring ethers. Part 3. Disproof of the proposed 2,8-disubstituted oxocane structure for gloeosporone. Synthesis of pseudo-gloeosporone
R. W. Carling, J. S. Clark, A. B. Holmes, D. Sartor, J. Chem. Soc., Perkin Trans. 1 1992, 95-101.
Link: 10.1039/P19920000095

4
Synthesis of medium ring ethers. Part 2. Synthesis of the fully saturated carbon skeleton of Laurencia non-terpenoid ether metabolites containing seven-, eight- and nine-membered rings
R. W. Carling, J. S. Clark, A. B. Holmes, J. Chem. Soc., Perkin Trans. 1 1992, 83-94.
Link: 10.1039/P19920000083

3
New procedure for the direct generation of titanium enolates. Diastereoselective bond constructions with representative electrophiles
D. A. Evans, F. Urpi, T. C. Somers, J. S. Clark, M. T. Bilodeau, J. Am. Chem. Soc. 1990, 112, 8215-8216.
Link: 10.1021/ja00178a082

2
Diastereoselective aldol reactions using .beta.-keto imide derived enolates. A versatile approach to the assemblage of polypropionate systems
D. A. Evans, J. S. Clark, R. Metternich, V. J. Novack, G. S. Sheppard, J. Am. Chem. Soc. 1990, 112, 866-868.
Link: 10.1021/ja00158a056

1
A strategy for the asymmetric synthesis of medium ring oxygen heterocycles: Enantioselective total synthesis of (+)-octahydrodeacetyldebromolaurencin
J. S. Clark, A. B. Holmes, Tetrahedron Lett. 1988, 29, 4333-4336.
Link: 10.1016/S0040-4039(00)80490-6