The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.

Cronin Group Builds Chemputer to Chemify Chemical Space

Cronin group researchers have built a “Chemputer” chemical computer system, coupled with a chemical programming language, allowing researchers to reliably and automatically synthesise organic molecules. In the research, published in Science, this approach was used to synthesise three pharmaceutical compounds – Nytol, rufinamide, and sildenafil – without any human interaction, and with yields comparable to or better than those achieved manually. The digital code for these processes can be published, versioned, and transferred flexibly between platforms with no modification, thereby greatly enhancing reproducibility and reliable access to complex molecules.

This research represents a leap forward in the ultimate aim to develop a commercial, universal chemical computer, that could revolutionise chemistry.It has been covered by multiple news sites including Chemistry World and C&EN. Further information and code can be found on the project homepage and on the Chemputer twitter feed.

Click the news item image to see the Chemputer process in action.

Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Advanced Research Centre (ARC)
Level 5, Digital Chemistry
University of Glasgow
11 Chapel Lane
Glasgow G11 6EW
Tel: +44 141 330 6650

Latest Publications


476. An artificial intelligence enabled chemical synthesis robot for exploration and optimization of nanomaterials


475. An autonomous portable platform for universal chemical synthesis


474. Robotic synthesis of peptides containing metal-oxide-based amino acids


473. Selection of assembly complexity in a space of tetrapeptides


472. Digitization and validation of a chemical synthesis literature database in the ChemPU


471. Formalising the pathways of life to using assembly spaces


470. Engineering Highly Reduced Molybdenum Polyoxometalates via the Incorporation of d and f Block Metal Ions


469. Effective Storage of Electrons in Water by the Formation of Highly Reduced Polyoxometalate Clusters

468. A Probabilistic Chemical Programmable Computer


467. Digitizing Chemical Synthesis in 3D Printed Reactionware

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