The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Cronin group researchers discover spontaneously assembled organic-inorganic “DNA”

Genetic material in the form of DNA and RNA is essential for life and evolution, but how did it first arise? This is a big mystery and poses a classic ‘chicken and egg’ conundrum: what type of molecule could have determined the sequence of the very molecule in which sequence is encoded? Researchers in the Cronin Group have reported an organic-inorganic compound whose structure closely resembles the naturally occurring Z-form of DNA which forms simply by mixing molybdate with GMP at low pH. It is hoped that the structure could open new avenues in the exploration of the transition between biologically inert matter and living systems.

Link to full paper

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Cronin Laboratory
School of Chemistry
Joseph Black Building
University of Glasgow
Glasgow G12 8QQ
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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442. A robotic prebiotic chemist probes long term reactions of complexifying mixtures

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441. Identifying molecules as biosignatures with assembly theory and mass spectrometry

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440. A molecular computing approach to solving optimization problems via programmable microdroplet arrays

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439. Influence of the Contact Geometry and Counterions on the Current Flow and Charge Transfer in Polyoxometalate Molecular Junctions: A Density Functional Theory Study

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438. Elucidating the Paramagnetic Interactions of an Inorganic-Organic Hybrid Radical-Functionalized Mn-Anderson Cluster

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437. Automatic Generation of 3D-Printed Reactionware for Chemical Synthesis Digitization using ChemSCAD

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436. Optimization of Formulations Using Robotic Experiments Driven by Machine Learning DoE

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435. Digitizing Chemistry Using the Chemical Processing Unit: From Synthesis to Discovery

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434. Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine

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433. Peptide sequence mediated self-assembly of molybdenum blue nanowheel superstructures


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