The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Digitalization of Chemistry

Prof Lee Cronin has featured on the Thomson Reuters “State of Innovation” website, where he discusses 3D-printing medicine and the development of the “chemical internet”.

The vision is to develop cheap, universal, and accessible chemical robots that will allow the Design, Discovery and Digitization of Chemical Space. One of the things that made the internet possible was that html, the standard language to create web pages, was very cheap and easy. In the same way, the Cronin Group is focused on developing cheap and easy-to-use robots that can do chemistry. “If the robots are too complicated they will fail and no one will use them,” Cronin pointed out.

The digitalization of the chemical space may represent a major change in the discovery process in chemistry. In the future, it might be possible to develop an application for a robot to create a molecule and do design according to a specification. Once a discovery is made, the coordinates of the new molecule in the chemical space could be stored as a code, making reproducibility cheap and easy, and hence changing the manufacturing process as we know it. The code could be used again and again. The potential of this system in the pharmaceutical industry is massive. Complicated drug manufacturing processes could be simplified and done at once. Drug discovery and formulation is a very complex process that demands a significant investment in effort, time and money. By using inexpensive robotics and improving reproducibility, the cost of either drug discovery, formulation or manufacture could be greatly reduced.

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Cronin Laboratory
School of Chemistry
Joseph Black Building
University of Glasgow
Glasgow G12 8QQ
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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442. A robotic prebiotic chemist probes long term reactions of complexifying mixtures

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441. Identifying molecules as biosignatures with assembly theory and mass spectrometry

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440. A molecular computing approach to solving optimization problems via programmable microdroplet arrays

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439. Influence of the Contact Geometry and Counterions on the Current Flow and Charge Transfer in Polyoxometalate Molecular Junctions: A Density Functional Theory Study

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438. Elucidating the Paramagnetic Interactions of an Inorganic-Organic Hybrid Radical-Functionalized Mn-Anderson Cluster

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437. Automatic Generation of 3D-Printed Reactionware for Chemical Synthesis Digitization using ChemSCAD

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436. Optimization of Formulations Using Robotic Experiments Driven by Machine Learning DoE

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435. Digitizing Chemistry Using the Chemical Processing Unit: From Synthesis to Discovery

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434. Convergence of multiple synthetic paradigms in a universally programmable chemical synthesis machine

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433. Peptide sequence mediated self-assembly of molybdenum blue nanowheel superstructures


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