The Cronin Group

Research in the Cronin Group is motivated by the fascination for complex chemical systems, and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks.


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Unlocking the Potential of Chemputation: Achieving Universality in Chemical Synthesis

Chemputation refers to the automation of chemical synthesis by translating chemical pathways into executable instructions that run on a programmable device known as a “chemputer.” But can a chemputer, using a chemical programming language, potentially synthesize any molecule that is theoretically possible?

In a new paper published on arXiv, Prof. Cronin explores this idea by defining what it means for a chemputer to achieve an analogue of Turing completeness, demonstrating its universality in chemical synthesis. He also outlines the requirements for dynamic error correction during “chempilation” steps to ensure accurate and reliable synthesis. This universality highlights the chemputer’s potential as a ground-breaking tool for automating and scaling up chemical production, opening new possibilities across various scientific fields.

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Prof. Leroy (Lee) Cronin

Prof Leroy (Lee) Cronin
Regius Chair of Chemistry
Advanced Research Centre (ARC)
Level 5, Digital Chemistry
University of Glasgow
11 Chapel Lane
Glasgow G11 6EW
Tel: +44 141 330 6650
Email: lee.cronin@glasgow.ac.uk

Latest Publications

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529. Chemputer and chemputation—A universal chemical compound synthesis machine

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528. Verification and execution of the scientific literature via chemputation augmented by large language models

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527. Chemical programming of kinase inhibitors in a modular chemputer-based system

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526. Organophosphonate Ligation Approach for the Controlled Assembly of Gigantic Polyoxometalate Clusters

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525. Spontaneous assemblies of gigantic polyoxomolybdates; from structure and properties to synthetic methods

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524. ElectroChemputer with integrated monitoring for programmable electrochemistry

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523. Achieving Operational Universality through a Turing Complete Chemputer

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522. AI-driven robotic crystal explorer for rapid polymorph identification

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521. Rapid Exploration of the Assembly Chemical Space of Molecular Graphs

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520. Programmable Microwaveable Chemistry in the Chemputer


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